丙种球蛋白治疗先天性心脏病患儿术后肺部感染的临床治疗效果分析  

Clinical effect of gamma globulin on treatment of congenital heart disease children with postoperative pulmonary infections

作　　者：侯小东[1] 尤涛[1] 王新宽[1] 刘兴光[1] 移康[1] 丁凡[1] 

机构地区：[1]甘肃省人民医院心血管外科,甘肃兰州730000

出　　处：《中华医院感染学杂志》2016年第2期435-437,共3页Chinese Journal of Nosocomiology

基　　金：甘肃省卫生行业计划基金资助项目(2010GS05162)

摘　　要：目的分析并探讨丙种球蛋白治疗先天性心脏病患儿术后肺部感染的临床效果,为制定合理、有效肺部感染的治疗方案提供参考。方法选取2010年1月-2015年1月在医院进行先天性心脏病手术患儿60例,分为观察组与对照组,各30例,两组患儿均给予常规的支持治疗,术后给予吸氧、雾化吸入、利尿液、抗菌药物等,在此基础上,观察组给予丙种球蛋白(IVIG)治疗,IVIG 400mg/kg,每日1次,最大剂量不超过10g/d,观察两组患儿各项指标恢复时间。结果观察组非肺动脉高压患儿呼吸困难消失时间为(3.04±1.02)d,肺部啰音消失时间为(4.16±1.37)d,X线胸片异常消失时间为(4.64±1.53)d,住院时间为(6.17±1.86)d;观察组肺动脉高压患儿呼吸困难消失时间为(4.25±1.66)d,肺部啰音消失时间为(8.32±2.41)d,X线胸片异常消失时间为(11.42±2.73)d,住院时间为(15.18±3.37)d;观察组患儿呼吸困难消失时间、肺部啰音消失时间、X线胸片异常消失时间以及住院时间明显短于对照组,差异有统计学意义(P<0.05)。结论丙种球蛋白治疗先天性心脏病术后肺部感染临床效果显著,各项指标恢复较快,值得临床应用。OBJECTIVE To observe the clinical effect of gamma globulin on treatment of the congenital heart disease children with postoperative pulmonary infections so as to provide guidance for reasonable and effective treatment of the pulmonary infections.METHODS A total of 60 children with congenital heart disease who underwent the surgery in the hospital from Jan 2010 to Jan 2015 were enrolled in the study and divided into the observation group and the control group,with 30 cases in each.Both groups were given the conventional supportive treatment and then were treated with oxygen inhalation,diuretics,and antibiotics after the surgery,on this basis,the observation group was treated with additional intravenous gamma globulin（IVIG）,IVIG 400 mg/kg,once a day,the maximum dose not exceeding 10g/d.The time of recovery of indicators were observed and compared between the two groups of children.RESULTS The time of disappearance of dyspnea of the non-pulmonary hypertension patients was（3.04 ±1.02）days in the observation group,the time of disappearance of pulmonary rales（4.16±1.37）days,the time of disappearance of chest X-ray abnormalities（4.64±1.53）days,the hospitalization duration（6.17±1.86）days;the time of disappearance of dyspnea of the pulmonary hypertension children was（4.25±1.66）days in the observation group,the time of disappearance of pulmonary rales（8.32±2.41）days,the time of disappearance of chest X-ray abnormalities（11.42±2.73）days,the hospitalization duration（15.18±3.37）days.The time of disappearance of dyspnea,time of disappearance of pulmonary rales,time of disappearance of chest X-ray abnormalities,and hospitalization duration of the observation group were significantly shorter than those of the control group（P〈0.05）.CONCLUSIONThe gamma globulin can achieve significant clinical effect on treatment of the congenital heart disease children with postoperative pulmonary infection,with the recovery of the indicators rapid,and it is worthy to be promoted in the hospital.

关 键 词：丙种球蛋白 先天性心脏病 肺部感染 

分 类 号：R619.3[医药卫生—外科学]