手足口病患儿血清模式识别受体的检测与易感因素分析  

Detection of serum pattern recognition receptors of children with hand-foot-mouth disease and predisposing factors

作　　者：冯利平[1] 周华斐 童夏生[1] 王鑫华[3] 赵美贞[1] 江丹红 

机构地区：[1]台州市中西医结合医院儿科,浙江台州317523 [2]路桥医院儿科,浙江台州317000 [3]台州市中西医结合医院检验科,浙江台州317523

出　　处：《中华医院感染学杂志》2016年第2期449-451,共3页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅基金资助项目(2009B169);温岭市科技局基金资助项目(2013-1-62)

摘　　要：目的探讨手足口病患儿血清模式识别受体的表达及易感因素,提高临床对手足口病的防治能力。方法选取2011年10月-2012年5月56例手足口病患儿(手足口病组)和30名健康体检儿童(对照组)血清,酶联免疫吸附法测定胶原凝集素、Dectin及膜蛋白细胞分化抗原14(CD14)的表达,设计统一的调查表,对手足口病患儿的性别、年龄、外来流动人口、就学情况、住宿条件、个人卫生习惯等进行问卷调查;采用SPSS16.0软件进行统计分析。结果手足口病组胶原凝集素、Dectin及CD14蛋白浓度依次为(83.11±44.38)ng/ml、(38.78±20.14)pg/ml、(2.16±1.11)ng/ml,均显著高于对照组;手足口病的发病年龄≥3岁显著高于<3岁,幼托儿童显著高于散居儿童,外来流动人口显著高于本地人口,住宿条件差的患儿显著高于住宿条件好的患儿,个人卫生习惯差的患儿显著高于卫生习惯好的患儿,不了解手足口病的监护人显著高于了解该疾病的监护人,未采取预防措施的显著高于采取预防措施的(P<0.05);而患儿性别及监护人的文化程度、月经济收入之间差异无统计学意义。结论手足口病易感因素复杂,良好的个人卫生对疾病预防有着重要意义,胶原凝集素、Dectin及CD14在手足口病中表达提升,监测模式识别受体可能对病情判断有一定的参考价值。OBJECTIVE To explore the expression of serum pattern recognition receptors of the children with handfoot-mouth disease（HFMD）and analyze the predisposing factors so as to prevent the hand-foot-mouth disease.METHODS From Oct 2011 to May 2012,the serum specimens were collected from 56 children with HFMD（the HFMD group）and 30 health children（the control group）,then the expressions of collectin,dectin,and membrane protein cell differentiation antigen 14（CD14）were detected by using enzyme-linked immunosorbent assay,the unified questionnaire was designed to conduct the questionnaire survey of the children with HFMD,involving the genders,age,foreign nomadic population,schooling condition,living condition,and personal hygienic habit;the statistical analysis was performed with the use of SPSS16.0software.RESULTS The concentrations of the collectin,dectin,and CD14 of the HFMD group were（83.11±44.38）ng/ml,（38.78±20.14）pg/ml,and（2.16±1.11）ng/ml,respectively,significantly higher than those of the control group.The incidence of HFMD was significantly higher in the children aged no less than 3years old than in the children aged less than 3years old;the incidence of HFMD was significantly higher in the nursery school children than in the scattered living children;the incidence of HFMD was significantly higher in the foreign nomadic population than in the local population;the incidence of HFMD was significantly higher in the children with poor living condition than in the children with good living condition;the incidence of HFMD was significantly higher in the children with poor personal hygienic habit than in the children with good personal hygienic habit;the incidence of HFMD was significantly higher in the children whose guardians were not aware of the HFMD than in the children whose guardians were aware of the HFMD;the incidence of HFMD was significantly higher in the children for whom the prevention measures were not taken than in the children for whom the prevention measures were taken（P〈0.

关 键 词：手足口病 模式识别受体 易感因素 

分 类 号：R181.32[医药卫生—流行病学]