盘状结构域受体与动脉粥样硬化关系的研究进展  

Research Progress of the Relation Between Discoidin Domain Receptor and Atherosclerosis

作　　者：王辉波[1] 杨俊[1] 杨简[1] 

机构地区：[1]三峡大学心血管病研究所三峡大学第一临床医学院心内科,湖北省宜昌市443003

出　　处：《中国全科医学》2015年第36期4514-4516,共3页Chinese General Practice

基　　金：国家自然科学基金资助项目(81170133;81200088;81470387);宜昌市科技研究与开发项目(A12301-01);湖北省首届医学领军人才基金(鄂卫生计发[2013]4号)

摘　　要：动脉粥样硬化(AS)是心脑血管疾病的病理基础,因具有高发病率、高病死率而引起人们的关注。盘状结构域受体(DDRs)是近年来发现的一种新型受体型酪氨酸激酶(RTK)超家族的一员,能与胶原蛋白特异性结合,激活一系列细胞内外信号传导,并参与多种细胞功能如细胞黏附、增殖、分化、迁移和内环境的稳态。编码DDRs的基因突变或过度表达导致其功能的改变会引发相关几种疾病,包括AS、炎症、肿瘤和组织纤维化。本文主要对DDRs的结构、分类与分布、功能及其与AS的关系进行综述,阐述DDRs在AS中的作用及其机制,并为AS提供了一种新的治疗靶点和策略。Atherosclerosis（ AS） is the major cause for cardiovascular and cerebrovascular diseases,it has caused much concern because of its high morbidity and mortality. Discoidin domain receptors（ DDRs） belongs to the family of receptor tyrosine kinases（ RTK） which was found in recent years. Upon collagen binding,cellular internal and external signal transduction of DDRs is activated,and DDRs is involved in various cell functions,including cell adhesion,proliferation,differentiation,migration,and the steady state of internal environment. Altered DDRs function resulting from either mutations or overexpression has been implicated in several types of disease,including atherosclerosis,inflammation,cancer and tissue fibrosis. The paper made a review of DDR＇s structure,category,distribution,function and relation with AS,discussed the role and mechanism of DDRs in AS and provided a new therapeutic target and strategy for AS.

关 键 词：动脉粥样硬化 盘状结构域受体 治疗靶点 

分 类 号：R543.5[医药卫生—心血管疾病]