2型糖尿病并发代谢综合征患者血清游离脂肪酸与高敏C反应蛋白特征  

Characteristics of serum free fatty acid and high-sensitivity C-reactive protein in patients with type 2 diabetes mellitus and metabolic syndrome

作　　者：楼大钧[1] 朱麒钱[1] 龚维坤[3] 叶飞[2] 董海燕[1] 黄迪华[1] 斯徐伟[1] 

机构地区：[1]绍兴市人民医院内分泌代谢科,浙江绍兴312000 [2]绍兴市人民医院中心实验室,浙江绍兴312000 [3]宁波大学医学院附属鄞州医院内分泌代谢科,浙江绍兴312000

出　　处：《中华临床营养杂志》2015年第6期351-355,共5页Chinese Journal of Clinical Nutrition

基　　金：基金项目：中华医学会临床医学科研专项研究资金（13050750460）;浙江省医药卫生科学研究基金（2015RCA025）;浙江省中医药科学研究资助项目（2015ZA205）;绍兴市科技局资助项目（2013870074、2014870070）

摘　　要：目的研究2型糖尿病并发代谢综合征（MS）患者与2型糖尿病不并发MS患者血清游离脂肪酸（FFA）与高敏c反应蛋白（hs—CRP）水平的变化。方法选取2013年1至6月绍兴市人民医院住院控制血糖的120例2型糖尿病患者，根据是否并发MS，分成MS组56例和非MS组64例，用酶法测定血清FFA浓度，同时用颗粒增强免疫沉淀法测定其血清hs-CRP水平。结果MS组FFA水平高于非MS组[（0．60±0．25）mmol／L比（0．45±0．21）mmol／L，P=0．033]；MS组hs-CRP水平也高于非MS组[5．29（4．69～5．82）mg／L比0．73（0．42—1．26）mg／L，P=0．000]。所有患者中，并发中心性肥胖患者hs—CRP水平高于无中心性肥胖患者[4．34（0．91～5．46）mg／L比1．80（0．82～3．27）mg／L，P=0．014]，并发高血压患者hs—CRP水平也高于无高血压患者[5．21（3．18～5．96）mg／L比2．93（0．89～4．98）mg／L，P=0．012]。结论2型糖尿病并发MS患者血清FFA、hs-CRP明显升高，可能在2型糖尿病、MS机制中起重要作用。Objective To investigate characteristics of free fatty acid （FFA） and high-sensitivity C- reactive protein （hs-CRP） in patients with type 2 diabetes mellitus and metabolic syndrome （MS） compared to those with type 2 diabetes mellitus without MS. Methods Totally 120 patients with type 2 diabetes melli- tus who received blood glucose control in Shaoxing People＇s Hospital from January to June 2013 were recruited and divided into MS group （ n = 56） and non-MS group （ n = 64）. The serum FFA profile of the patients was measured by enzymatic assay, and the serum hs-CRP level measured by particle-enhanced immuno-precipita- tion assay. Results The level of FFA was higher in the MS group than that in the non-MS group [ （0. 60 ±0. 25） mmol/L vs. （0.45 ±0. 21） mmol/L, P = 0. 033 ]. The level of hs-CRP was higher in the MS group than that in the non-MS group [ 5.29 （4. 69 - 5.82） mg/L vs. O. 73 （0. 42 - 1.26） mg/L, P = 0. 000 ]. The level of hs-CRP was higher in the patients with central obesity than that in those without central obesity [ 4. 34 （ 0. 91 - 5.46 ） mg/L vs. 1.80 （ 0, 82 - 3.27 ） mg/L, P = 0. 014 ], also higher in hypertensive pa- tients than in non-hypertensive patients [5.21 （3. 18 -5.96） mg/L vs. 2. 93 （0. 89 -4. 98） mg/L, P = 0. 012]. Conclusions Serum FFA and hs-CRP concentrations may be significantly higher in type 2 diabetesmellitus patients with MS. The increased levels of FFA and hs-CRP may play an important role in the pathogen- esis of type 2 diabetes mellitus and MS.

关 键 词：代谢综合征 2型糖尿病 血清游离脂肪酸 超敏C反应蛋白 

分 类 号：R589[医药卫生—内分泌]