慢性阻塞性肺疾病患者脂代谢和血清促血管生成素2水平与病情严重程度的关系  

Relationship Between Lipid Metabolism and Serum Angiogenin 2 Levels in Patients With COPD and Illness Severity

作　　者：李春芝[1] 刘洪英[1] 刘军肖[1] 

机构地区：[1]河北省人民医院,河北省石家庄市050051

出　　处：《中国全科医学》2015年第34期4210-4215,共6页Chinese General Practice

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者脂代谢和血清促血管生成素2(ANG2)水平与病情严重程度的关系。方法采用随机数字表法选取2012年11月—2014年1月河北省人民医院收治的COPD患者185例作为COPD组,另选取同期本院体检健康者30例作为对照组。COPD组患者给予沙美特罗替卡松联合噻托溴铵粉吸入剂吸入治疗。分别于对照组入选次日和观察组治疗前(T0)和治疗1周(T1)、2周(T2)、1个月(T3)和3个月(T4)采集空腹静脉血5 ml,检测血清ANG2水平和血浆总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,并评估BODE指数(B为体质指数,O为气流阻塞程度,D为呼吸困难,E为运动能力)。比较不同BODE指数分级COPD患者治疗前后的血脂水平和血清ANG2水平并分析COPD患者脂代谢紊乱、血清ANG2水平与其BODE指数的关系。结果 COPD组和对照组HDL-C、LDL-C水平比较,差异均无统计学意义(P>0.05);COPD组和对照组TC、TG、ANG2水平和BODE指数比较,差异均有统计学意义(P<0.05);其中与COPD组T0比较,COPD组T2、T3、T4TC、TG水平均升高,ANG2水平和BODE指数均降低,差异有统计学意义(P<0.05);对照组TC、TG水平均高于COPD组T0、T1、T2、T3、T4时,ANG2水平和BODE指数均低于COPD组T0、T1、T2、T3、T4时,差异有统计学意义(P<0.05)。T0和T4时,COPD组BODE指数分级分布比较,差异有统计学意义(U=9.25,P<0.01)。T0、T4时,不同BODE指数分级患者HDL-C、LDL-C水平比较,差异均无统计学意义(P>0.05);不同BODE指数分级患者TC、TG、ANG2水平比较,差异均有统计学意义(P<0.05);其分级越高,TC、TG水平越低,ANG2水平越高,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,COPD患者TC、TG水平与BODE指数呈负相关(r=-0.941、-0.940,P<0.05),血清ANG2水平与BODE指数呈正相关(r=0.921,P<0.05)。COPD患者治疗期间不良反应症状均较轻微且均可在不加干预的情况�Objective To investigate lipid metabolism and serum angiogenin 2（ANG2）level in patients with chronic obstructive pulmonary disease（ COPD） and their relationship with illness severity. Methods Using convenience number table method,we enrolled 185 COPD patients who were admitted into Hebei General Hospital from November 2012 to January 2014. We also enrolled 30 healthy people who received physical examination in the same period in the hospital as control group. COPD group was administrated with inhalation powder of salmeterol and fluticasone propionate combined with tiotropium bromide. Fasting venous blood was taken on the next day after the inclusion from control group and was taken before treatment（T0）,after 1-week treatment（T1）,2-week treatment（T2）,1 -month treatment（T3）and 3 -month treatment（T4）from COPD group. Then serum ANG2 level,TC,TG,HDL-C and LDL-C were detected,and BODE indexes were evaluated. Blood lipid level and serum ANG2 level were compared among COPD patients with different BODE index grades before and after treatment,and relationship between dyslipidemia and serum ANG2 level of the patients and BODE index. Results COPD group and control group were not significantly different in the levels of HDL-C and LDL-C（ P﹥0. 05 for all）;COPD group and＆nbsp;control group were significantly different in the levels of TC,TG and ANG2 and BODE indexes（ P﹤0. 05 for all）;in COPD group,the levels of TC and TG at T2,T3 and T4 were higher than those of T0（P﹤0. 05）,and the ANG2 level and BODE index of T2,T3 and T4 were lower than those of T0（P﹤0. 05）;control group was higher in the levels of TC and TG and were lower in ANG2 level and BODE index than COPD group at T0 ,T1 ,T2 ,T3 and T4 （ P﹤0. 05 for all）. There were significant differences in the BODE index grading distribution between T0 and T4（U =9. 25,P ﹤0. 01）. At T0 and T4,patients with different BODE index grades were not significantly different in the levels of HDL-C and LDL-C（ P﹥0. 05 for all�

关 键 词：肺疾病 慢性阻塞性 脂代谢 促血管生成素2 病情严重程度 

分 类 号：R563.9[医药卫生—呼吸系统]