睡眠剥夺对健康青年人心理健康和血清皮质醇影响及相关性研究  

Effects of sleep deprivation on mental health and serum cortisol and the correlations between them in military personnel

作　　者：杨佳琳[1] 宋红涛[2] 张理义[3] 白婧[1] 李牧[1] 陈韵岱[1] 杨庭树[1] 范利[1] 

机构地区：[1]解放军总医院南楼保健科,北京100853 [2]江苏大学临床医学院 [3]解放军102医院全军心理疾病防治中心

出　　处：《中华保健医学杂志》2015年第6期456-459,共4页Chinese Journal of Health Care and Medicine

基　　金：国家科技支撑计划(2009BAI86B04)

摘　　要：目的研究睡眠剥夺对健康青年人心理健康状况和血清皮质醇含量的影响,并进一步探索血清皮质醇含量与心理健康状况的关系。方法随机整群抽取某部队陆军160名进行24 h完全睡眠剥夺作为睡眠剥夺组和60名给予正常睡眠(睡眠≥7 h)作为对照组,试验从当天下午2∶00至次日下午2∶00,试验结束后立即运用《军人心理疾病预测量表》陆军常模同时评定睡眠剥夺组和对照组的心理健康状况,睡眠剥夺组分别于试验次日晨7∶00和正常睡眠洗脱(睡眠≥7 h)5 d后次日晨7∶00抽取静脉血测定皮质醇含量,对所得数据进行统计学分析。结果(1)睡眠剥夺组心理疾病预测总分及精神病性、抑郁、躁狂、神经症、人格偏移因子分明显高于对照组(P<0.05);(2)睡眠剥夺组心理疾病预测总分及躁狂、人格偏移因子分明显高于陆军常模(P≤0.01);(3)睡眠剥夺组睡眠剥夺中的血清皮质醇含量高于正常睡眠洗脱后(t=2.05,P=0.04);(4)睡眠剥夺组躁狂因子得分与剥夺时血清皮质醇升高量呈正相关(r=0.37,P=0.00);(5)睡眠剥夺时血清皮质醇的ROC曲线下面积为0.95,以血清皮质醇含量500.56 nmol/L为临界值时诊断躁狂状态的相关性最高。结论睡眠剥夺可显著降低青年军人心理健康水平和引起血清皮质醇升高,睡眠剥夺时血清皮质醇升高在导致躁狂症状的过程中起正向调节作用,睡眠剥夺时血清皮质醇含量达500.56 nmol/L与预测躁狂状态有较好的相关性。Objective To study the effects of sleep deprivation on the status of mental health and the level of serum cortisol and explore the correlations between the serum cortisol level and mental health in martial personnel. Methods By random cluster sampling, 160 land army personnel who should stay awake from 14：00 o＇clock on first day until 14：00 o＇clock next day were selected as the sleep deprivation group,and 60 land army personnel who had normal sleep （sleep at least 7 hours per night） were selected as the control group. The sleep deprivation group and control group were investigated at the same tiMe by Military Personnel Mental Disorder Prediction Scale after the experiment. Blood samples were drawn from the sleep deprivation group at 7：00 o＇clock on second day and at 7：00 o＇clock after five days normal sleep （sleep at least 7 hours per night） and were used to measure the level of serum cortisol respectively. The acquired data were analyzed by SPSS statistic 17.0 program. Results （1） The total scores of mental disorder prediction and factor scores of psychosis,depression,mania,neurosis,personality disorder of sleep deprivation group were much higher than those in control group （P 〈 0.05）; （2） Compared with the land army norm,the total scores of mental disorder prediction and factor scores of mania,personality disorder of sleep deprivation group were significantly higher （P≤ 0.01）;（3） The serum cortisol level of sleep deprivation group during the sleep deprivation was significantly higher than after washout of normal sleep （t = 2.05 ,P = 0.04） ; （4）In sleep deprivation group the factor scores of mania was positively correlated with the level of serum cortisol during the sleep deprivation （r = 0.37,P = 0.00）. （5） Areas under the curve （AUC） of serum cortisol during the sleep deprivation were 0.95 with serum cortisol level of 500.56 nmol/L as a cut-off value to diagnose mania and good correlation with mania. Conclusion Sleep deprivation can significan

关 键 词：睡眠剥夺 心理健康 血清皮质醇 健康青年人 

分 类 号：R395[哲学宗教—心理学]