IL-1α和IL-1β指标变化对慢性乙型肝炎患者的诊断及其临床意义  

Diagnosis and Clinical Significance of Serum IL-1α and IL-1β Levels in Patients with Chronic Hepatitis B

作　　者：柴晓哲[1] 张雪华[1] 

机构地区：[1]苏州市第五人民医院,江苏苏州215007

出　　处：《抗感染药学》2015年第6期878-881,共4页Anti-infection Pharmacy

基　　金：苏州市科教兴卫项目(项目编号:kjxw2012031)资助

摘　　要：目的:评价IL-1α和IL-1β指标变化对慢性乙型肝炎(CHB)患者的诊断及其临床意义。方法:选取2012年8月—2013年7月间收治的CHB患者40例为观察组和对照组(健康志愿者)40例;两组患者均采用酶联免疫法(ELISA)测定其血清中IL-1α和IL-1β含量,分析IL-1α和IL-1β含量的变化对诊断CHB的临床意义。结果:观察组患者血清中IL-1α和IL-1β含量均高于健康对照组(P<0.01);其含量的变化与CHB患者临床特征(HBVDNA、ALT和AST)无相关性。结论:IL-1α和IL-1β可能参与CHB的疾病进程,这为研究CHB的病情变化的监控及其有效治疗提供新的依据。Objective： To evaluate the diagnosis and clinical significance of serum IL- 1α and IL- 1β levels in patients with chronic hepatitis B（CHB）. Methods： 40 patients of CHB were selected as the observation group and 40 normal healthy volunteers as controls group during August 2012 to July 2013. The serum IL-1α and IL-1β levels were assessed in 40 patients with CHB and 40 normal healthy volunteers by ELISA assay. The IL-1α and IL-1 content changes were analyzed on the clinical significance in the diagnosis of CHB. Results： The serum IL-1α and IL-1β contents in CHB group were significantly higher than those of the normal volunteers（P〈0.01）, and the correlation analysis showed that the contents of serum IL-1α and IL-1β were not associated with HBV-DNA, ALT and AST contents （P〉0.05）. Conclusion： The 1L-1α and IL-1β may participate in the procession of CHB, and provide new clues for the monitoring and effective therapy of CHB.

关 键 词：IL-1Α IL-1Β 慢性乙型肝炎 

分 类 号：R927.1[医药卫生—药学]