新型含氮杂环结构的1,1-二氯丙烯类化合物的合成及其生物活性  

Synthesis and Biological Activity of Novel 1,1-Dichloropropene Derivatives Containing N-Heterocycles

作　　者：戴红[1] 葛书山 戴宝江[2] 李钰[1] 施磊[1] 李阳[1] 方源[1] 石玉军[1] 

机构地区：[1]南通大学化学化工学院,南通226019 [2]南通职业大学化学与生物工程学院,南通226007

出　　处：《有机化学》2015年第12期2610-2616,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21202089;21372135);南通市科技计划(Nos.AS2013002;AS2014011)资助项目~~

摘　　要：为了从1,1-二氯丙烯类化合物中寻找新的活性物质,本文采用活性基团拼接方法,制备了一系列未见文献报道的新型含氮杂环结构的1,1-二氯丙烯衍生物.通过1H NMR,13C NMR和元素分析等手段对目标化合物的结构进行了验证.初步的生物活性测试结果显示,在测试浓度为500μg/m L时大多数目标化合物表现出良好的杀粘虫活性,其中化合物6a,6b,6c,6d,6e,6f,6i,6l,6m和6o对粘虫的杀死率均为100%.此外,部分目标物还表现出一定的杀蚜虫活性.In search of novel 1,1-dichloropropene compounds derivatives containing N-heterocycles were synthesized by the with potent bioactivities, a series of novel 1,1-dichloropropene strategy of active substructure combination. The structures of the target compounds were confirmed by ^1H NMR, ^13C NMR and elemental analysis. Preliminary bioassay indicated that most of the title compounds showed good larvicidal activity against Oriental armyworm at the concentration of 500 pg/mL. For example, the inhibition rates against Oriental armyworm of compounds 6a, 6b, 6c, 6d, 6e, 6f, 6i, 61, 6m and 60 were all 100%. Besides, some target compounds displayed certain insecticidal activity against Aphis craccivora at the concentration of 500 μg/mL.

关 键 词：含氮杂环 1 1-二氯丙烯 合成 生物活性 

分 类 号：O626[理学—有机化学] TQ450.1[理学—化学]