遵义人群维生素D受体基因第八内含子多态性  

The eighth intron of Vitamin D receptor gene polymorphism in Zunyi population

作　　者：余晓[1] 吕纯莉[2] 吴莉莉[3] 韦若勋[3] 

机构地区：[1]遵义医学院生物化学教研室,贵州遵义563099 [2]遵义医学院附属医院检验科,贵州遵义563099 [3]遵义师范学院生命科学学院,贵州遵义563002

出　　处：《遵义医学院学报》2015年第6期604-606,共3页Journal of Zunyi Medical University

基　　金：遵义师范学院基础教育研究项目(NO:13ZYJ063)

摘　　要：目的探讨在遵义人群中维生素D受体(vitamin D recepter,VDR)基因第八内含子多态分布情况。方法收集119例遵义人群静脉血标本,用限制性片段长度多态性(RFLP)法检测VDR基因第八内含子多态性,分析该位点在遵义人群中的基因型频率和基因频率分布规律。结果遵义人群VDR基因的基因型频率分别为69.75%(TT)、26.89%(Tt)和3.36%(tt),基因频率分别为83.2%(T)和16.8%(t)。结论 VDR基因第八内含子多态性在遵义人群中分布具有多态性。Objective To investigate the polymorphism distribution in the eighth intron of Vitamin D Receptor（VDR）gene in Zunyi.Methods Collecting 119 blood samples in Zunyi area,the eighth intron polymorphism of VDR gene was tested by Restriction Fragment Length Polymorphism analysis,and the distribution of the genotypes and allele frequencies were analyzed.Results The frequencies of genotypes were 69.75%（TT）,26.89%（Tt）and 3.36%（tt）.The frequencies of the VDR gene were 83.2%（T）and 16.8%（t）.Conclusion The eighth intron of VDR gene in Zunyi population has polymorphisms.

关 键 词：维生素D 受体基因 第八内含子 遵义人群 基因频率 

分 类 号：R681.5[医药卫生—骨科学]