医用黏合剂α-氰基丙烯酸酯聚合热对血管损伤的研究  

Study on polymerization heat induced by a-cyanoacrylate in medical adhesive on vascular tissue lesion

作　　者：房卓群 梁向党[1] 孙赓[2] 宋垚垚 陈文[1] 郭占芳[1] 

机构地区：[1]解放军总医院骨科,北京100853 [2]解放军252医院骨科,河北保定071000 [3]海军总医院烧伤整形科,北京100853

出　　处：《医疗卫生装备》2015年第12期11-14,共4页Chinese Medical Equipment Journal

基　　金：科技部国际合作项目(2014DFA31230)

摘　　要：目的:观察黏合吻合术中α-氰基丙烯酸酯医用黏合剂聚合热对兔血管组织的再损伤。方法:取2.5~3.0 kg新西兰白兔40只随机分为A、B、C、D 4组,每组10只,切断兔左侧颈总动脉,随后吻合,并悬空吻合口,在吻合口及吻合口前后各1 cm处滴加医用黏合剂,覆盖且不压迫血管吻合口。A组滴1滴(20μl),B组滴2滴(40μl),C组滴4滴(80μl),D组滴生理盐水。待黏合剂凝固,观察血管通畅及搏动状况后,逐层缝合。术后4周进行超声检查,取吻合口组织进行大体观察及组织病理观察,观察吻合口损伤情况。结果:术后4组血管超声下均通畅,D组与A、B、C3组大体观察及组织学观察比较差异明显,D组与A、B、C 3组内膜增生差异有统计学意义(P<0.05)。结论:常规范围内不同剂量α-氰基丙烯酸酯黏合剂产生的聚合热对血管组织损伤较轻,在血管组织修复中可用于吻合和固定。Objective To study the polymerization heat induced by ct-cyanoael^clate in medical adhesive on vascular tissue lesion. Methods A total of 40 rabbits weighing 2.5 to 3.0 kg were randomly divided into A, B, C and D groups （n= 10）. Rabbits＇ left common carotid arteries were cut off, and dropped medical glue on and 1 cm before and after anastomotic stoma with impending anastomotic stoma. Group A was given 20 μl α-cyanoacrylate （1 drop）, group B was given 40 μl α-cyanoaerylate（2 drops）, group C was given 80 μl α-cyanoacrylate （4 drops）, group D was given Physiological saline. The conditions of vascular patency and vascular pulsing were observed after glue solidified, then the tissue and skin were sutured. Doppler ultrasound was performed 4 weeks after operation. The anastomotic gross observation, tissue pathology observation and the anastomotic lesion obselvation were carried out. Results Vascular patency of 4 groups un- der Doppler ultrasound were unhlocked. The gross observation and tissue pathology observation between group D and group A, C, B showed obvious differences, while the endometrial hyperplasia between group D and group A, C, B were statistically significant. Conchuslon Polymerization heat induced by different doses of α-cyanoacrylate in medical adhesive has mild damage on vascular tissues, and can be applied to anastomosis and fixation while repairing the blood vessels. [Chinese Medical Equipment Journal,2015,36（12） ~ 11-14]

关 键 词：组织黏合剂 氰基丙烯酸酯类 聚合热 血管 兔 

分 类 号：R318.08[医药卫生—生物医学工程]