一种测量动脉血氧饱和度的新方法  

New Method of Measuring Arterial Oxygen Saturation

作　　者：李刚[1,2] 包磊[1,2] 周梅[3] 林凌[1,2] 刘蕊[4] 赵春杰[5] 

机构地区：[1]天津大学精密测试技术及仪器国家重点实验室,天津300072 [2]天津大学天津市生物医学检测技术与仪器重点实验室,天津300072 [3]华东师范大学极化材料与器件教育部重点实验室,上海200241 [4]天津市人民医院检验学部,天津300120 [5]天津市人民医院查体中心,天津300120

出　　处：《光谱学与光谱分析》2016年第1期196-200,共5页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(30973964);天津市应用基础及前沿技术研究计划项目(11JCZDJC17100)资助

摘　　要：在传统的血氧饱和度测量方法中,首先计算对数光电容积脉搏波交、真流成分的比值(R值),然后通过实验建立血氧饱和度值与R值的线性回归模型,旨在消除光程的影响,将个体差异的影响降至最小化,是一种基于Lambert-Beer定律的降维处理。当考虑散射时,这种以交、直流成分的比值作为自变量的降维处理方式损失了信息量,引入了系统误差,限制了测量的精度。为了减小这种影响,从透射光电脉搏波所含信息量的角度,提出了使用双波长对数光电容积脉搏波的峰值和谷值作为自变量与血氧饱和度值建立线性回归模型的新方法。从23名健康志愿者中获得133例光电脉搏波及血氧饱和度参考值样本,从中随机抽取90例作为建模集,另外43例作为预测集,对比了新方法和R值法的建模和预测结果。随机抽取建模集并预测10次,新方法和R值法的平均预测相关系数分别为0.890 6和0.846 8,平均预测均方根误差分别为0.889 6%和1.037 3%,结果表明新方法的预测效果优于传统R值法,使用四个特征量建立血氧饱和度预测模型,能够提高测量的稳定性和精度,对基于有限波长光谱数据建模测量人体血液生理参数有指导意义。The traditional method of measuring arterial oxygen saturation is that Rvalue,the ratio of alternating component of the logarithmic photoplethysmography,is firstly computed and then the linear regression model is established by experiment.The Rvalue computation is a dimension reduction process based on Lambert-beer law,which aims at eliminating the influence of optical path andminimizing the impact of individual differences.When taking scattering into consideration,the dimension reduction process loses information,introduces the system error and limits the precision of measurement.In order to reduce the measurement error resulting from the scattering effects,this paper presents a new method that the peak and valley values of dualwavelength logarithmic photoplethysmography waves are used as the independent variables to develop a linear regression model to predict the arterial oxygen saturation.During the experiment,the in-vivo measurements were carried out on 23 healthy volunteer and 133 samples of photoplethysmography waves and the reference value of oxygen saturation were recorded.To compare the predictive performance between the new method and the Rvalue method,90 samples were randomly selected as modeling sets and the remaining 43 samples were used as prediction sets.Random selection of modeling sets and prediction are executed 10 times.The average related coefficients of the prediction sets of the new method and the Rvalue method are 0.890 6and 0.846 8,and the average root mean square errors are 0.889 6% and 1.037 3% respectively.Results indicate that the performance of the new method is better than the one of the Rvalue method,and the predictivemodel based on 4parameters can improve the stability and accuracy of measurement.And the new method has guiding significance to the measurement of human body＇s blood physiological information based on limited wavelength spectrum data.

关 键 词：血氧饱和度 光电脉搏波 偏最小二乘 无创测量 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]