四逆散影响慢性应激抑郁模型大鼠行为学研究  

Effects of Sini Powder on the behavior of rat depression model induced by chronic stress

作　　者：胡海燕[1] 徐志伟[1] 敖海清[1] 吴皓萌[1] 吉云鹏[1] 

机构地区：[1]广州中医药大学,广州510405

出　　处：《中华中医药杂志》2016年第1期271-274,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点基础研究发展计划(973计划)项目子课题(No.2011CB505103);国家自然科学基金资助项目(No.81173144);教育部2010年度新世纪优秀人才支持计划项(No.NCET-100088)~~

摘　　要：目的:探讨四逆散对慢性应激大鼠行为学的影响。方法:Wistar大鼠随机分成空白组,模型组,氟西汀组,四逆散低、中、高剂量组(以下简称四低、中、高组),每组10只。建立慢性心理应激动物模型,采用旷场实验、糖水消耗实验、Morris水迷宫实验进行检测。结果:造模15、30d后,模型组与空白组相比体质量减少(P<0.05)。旷场实验:造模30d,模型组、四低组、四高组与空白组相比总路程、平均速度、中央区时间与中央区路程均显著降低(P<0.05);四中组、氟西汀组与模型组相比4个指标均显著升高(P<0.05)。糖水消耗实验:造模30d,模型组、四中组与空白组相比糖水偏爱率显著降低(P<0.05);四低组、氟西汀组与模型组相比糖水偏爱率升高(P<0.05)。Morris水迷宫实验结果各组相比,但整体趋势与糖水偏爱率相似。结论:1四逆散可缓解慢性应激模型大鼠抑郁症状;2四逆散能改善慢性应激模型大鼠空间学习记忆能力;3四逆散不同剂量对模型大鼠行为学的改善不同。Objective：To investigate the effect of Sini Powder on behavior of rat depression model induced by chronic stress.Methods：Wistar rats were randomly divided into control group,model group,fluoxetine group,Sini Powder low,middle and high dose group,with 10 rats in each group.The model of chronic psychological stress was established.The changes of rat behavior were observed by open-field test,Sucrose preference test,and Morris water maze test.Results：Body weight：Compared with the control group,the body weight of model group was decreased（P〈0.05）.Open-field test：Compared to the control group,the total distance,average speed,duration and distance in the central area in the model group,Sini Powder low and high dose group were all decreased（P〈0.05）;Compared to the model group,four indicators above in Sini Powder middle dose group and fluoxetine group were all increased（P〈0.05）.Sucrose preference test：Compared with the control group,the sucrose preference rates in model group and Sini Powder middle dose group were reduced（P〈0.05）;Compared to the model group,the sucrose preference rates in Sini Powder low volume group and fluoxetine group were all increased（P〈0.05）.Morris water maze test had no statistical difference among the four groups,but the overall trend was same as the results of sucrose preference test.Conclusion：①Sini Powder could improve symptoms of depression induced by chronic psychological stress.②Sini Powder could improve learning and memory deficit induced by chronic psychological stress.③Different doses of Sini Powder improved the rat behavior changes induced by chronic psychological stress that was different.

关 键 词：四逆散 慢性应激 行为学 

分 类 号：R285.5[医药卫生—中药学]