养心通汤对冠状动脉介入术后再狭窄患者ET、MMP-9、APN水平的影响  

The Influence of Yangxintong Decoction on ET and MMP-9 and APN Levels of Patients with Coronary Intervention Postoperative Restenosis

作　　者：田子英[1] 关利君[1] 

机构地区：[1]内蒙古医科大学附属医院,内蒙古呼和浩特010050

出　　处：《河南中医》2015年第12期2932-2934,共3页Henan Traditional Chinese Medicine

摘　　要：目的:观察自拟养心通汤对冠状动脉(冠脉)介入术后再狭窄患者炎性介质因子的影响。方法:选择2014年2月—2015年2月就诊于本院的冠脉介入术后患者96例为研究对象,按照随机数字表法分为对照组和治疗组各48例。对照组给予阿托伐他汀钙片、氯吡格雷片、阿司匹林肠溶片等常规基础疗法,治疗组则在此基础上加用自拟养心通汤治疗,两组均连续治疗6个月。比较两组患者经治疗后的再狭窄率,监测治疗前后患者炎性因子水平变化。结果:治疗组患者用药后再狭窄率8.3%明显低于对照组患者再狭窄率27.1%,差异有统计学意义(P<0.05);治疗组患者用药后炎性因子C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)、白细胞介素-18(IL-18)水平显著低于治疗前及对照组患者,差异有统计学意义(P<0.05);治疗组患者用药后的内皮素(ET)、基质金属蛋白酶-9(MMP-9)水平较用药前显著降低,且明显低于对照组患者,血清脂联素(APN)水平则明显高于对照组患者,差异有统计学意义(P<0.05)。结论:自拟养心通汤利于防治冠脉介入术后患者的再狭窄症状,其机制与调控炎性介质因子水平紧密相关。Objective： To observe the influence of Self-made Yangxintong Decoction（ SYXTD） on ET and MMP-9 and APN levels of patients with coronary intervention postoperative restenosis. Methods： Ninety-six patients with coronary intervention operation who were treated in our hospital between Feb. of 2014 and Feb. of 2015 were chosen as the research objects,and divided into the control group and the treatment group,with 48 cases in each group. The ones in the control group were given atorvastatin calcium tabets,clopidogrel,aspirin enteric-coated metformin hydrochloride for routine Western medicine symptomatic treatment,while the ones in the treatment group were added SYXTD based on the treatment of the control group. The two groups were both treated for6 months continuously,then the restenosis rates after the treatment were compared,and inflammatory mediators factor level changes before and after the treatment were measured. Results： After taking medicines,the restenosis rate of the treatment group was8. 3%,which was much lower than that（ 27. 1%） of the control group,and the difference between them had statistical significance（ P〈0. 05）. The hs-CRP,IL-6,TNF-αand IL-18 levels of the treatment group were much lower than those of before the treatment and the control group,and the differences between them had statistical significance（ P〈0. 05）. The ET and MMP-9 levels of the treatment group were obviously reduced than before taking medicines,and much lower than those of the control group,but its APN level was much higher than that of the control group,the differences between them had statistical significance（ P〈0. 05）. Conclusion： SYXTD can prevent and treat coronary intervention postoperative restenosis symptoms,whose working mechanism has a close relationship with regulating inflammatory mediators factor,and is worth exploring clinically.

关 键 词：冠脉介入术后 养心通经验方 丹红注射液 炎性介质因子 

分 类 号：R259.414[医药卫生—中西医结合]