重症监护病房中心静脉导管相关性血流感染的病原菌分布及耐药性  

Distribution and drug resistance of pathogens of catheter-related bloodstream infection in ICU

作　　者：张兴翔 金敏[1] 

机构地区：[1]杭州市西湖区第二人民医院,浙江杭州310000

出　　处：《中国微生态学杂志》2016年第1期76-78,共3页Chinese Journal of Microecology

摘　　要：目的探讨重症监护病房(ICU)患者中心静脉导管相关性血流感染(CRBSI)病原菌的分布特点及其耐药性,为临床合理选用抗菌药物提供依据。方法回顾分析杭州市西湖区第二人民医院2010年1月至2014年12月ICU病房收治的CRBSI患者的临床资料,了解其病原菌的构成及其药物敏感情况。结果共分离出病原菌152株,其中革兰阴性杆菌占53.95%,革兰阳性球菌占40.13%,真菌占5.92%。药敏结果显示,主要革兰阴性杆菌对阿米卡星、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、亚胺培南耐药率较低,主要革兰阳性球菌对利福平、阿米卡星、呋喃妥因、替加环素、利奈唑胺和万古霉素耐药率较低。结论加强CRBSI细菌耐药性监测,合理使用抗菌药物,有助于CRBSI的早期诊治和降低患者死亡率。Objective To investigate the distribution and drug resistance of pathogens causing catheter-related bloodstream infection（CRBSI）in ICU so as to provide guidance for reasonable use of antibiotics.Methods The patients with CRBSI admitted in ICU from Jan.2010 to Dec.2014 were analyzed retrospectively,and the pathogens and antimicrobial susceptibility were detected.Results A total of 152 strains of pathogens were detected,including gram-negative bacillus（53.95%）,gram-positive cocci（40.13%）and fungus（5.92%）.Drug susceptibility results showed that the main gram-negative bacteria were sensitive to Amikacin,Piperacillin/tazobactam,Cefoperazone/sulbactam and Imipenem,while the main gram-positive were sensitive to Rifampicin,Amikacin,Nitrofurantoin,Tigecycline,Rinathiazoleamine and Vancomycin.Conclusion Strengthening the monitoring of drug resistance and using antibiotics reasonably will help in the early diagnosis and reduce the mortality of CRBSI.

关 键 词：导管相关性血流感染 病原菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]