免疫避孕疫苗的最新研究进展  

The latest research progress of immunocontraceptive vaccines

作　　者：徐萍萍[1] 毛克杰 梁志清[3] 杨利华[4] 

机构地区：[1]解放军第八一医院妇产科,南京210002 [2]山东省临沂市费县人民医院,273400 [3]第三军医大学西南医院妇产科,重庆400038 [4]河北省唐山工人医院,063000

出　　处：《免疫学杂志》2016年第2期168-172,共5页Immunological Journal

基　　金：国家自然科学基金(81270731)

摘　　要：免疫避孕疫苗是利用多种实验技术,从参与生殖过程各要素中筛选出蛋白抗原或表位抗原,通过免疫避孕对象,在生殖道局部或全身产生中和抗体,从而影响和破坏生殖过程,起到延长妊娠间隔和避孕的作用。本文对免疫避孕现状和未来发展做一综述。Immunocontraceptive vaccines are protein or epitope antigens screened from the elements involved in reproductive process by varieties of experimental technology. Then the object people or animal immunized with the vaccine will produce neutralizing antibody in the genital tract locally or systemically, which can influence and damage the reproductive process, thus exerts the effect of pregnancy interval prolonging and birth control. This article reviews the present situation and future development of immunocontraceptive vaccine.

关 键 词：避孕疫苗 免疫 抗原 配体 

分 类 号：R169.4[医药卫生—公共卫生与预防医学] R392