手足口病患儿淋巴细胞亚群与红细胞锌及超敏C反应蛋白水平分析  

Analysis of level change on peripheral blood lymphocyte subgroup,erythrocyte Zinc and hs-CRP concentrations in children with hand-foot-mouth disease

作　　者：况凡[1] 

机构地区：[1]湖北省孝感市中心医院检验科,432000

出　　处：《重庆医学》2016年第1期69-70,共2页Chongqing medicine

基　　金：湖北省自然科学基金项目(2011CDB324)

摘　　要：目的探讨手足口病患儿外周血淋巴细胞亚群与红细胞锌及超敏C反应蛋白(hs-CRP)的水平变化。方法选取该院诊疗的重型手足口病患儿为患儿组,另选取该院健康体检的健康儿童为对照组,检测外周血淋巴细胞亚群与红细胞锌及hsCRP水平。结果患儿组的总T细胞(CD3+)百分率、辅助/诱导T细胞(CD3+CD4+)百分率、抑制/细胞毒T细胞(CD3+CD8+)百分率、红细胞锌测定水平明显低于对照组(P<0.05);hs-CRP测定水平、B细胞(CD19+)百分率明显高于对照组(P<0.05)。结论重型手足口病患儿细胞免疫和体液免疫功能紊乱、红细胞锌缺乏、机体不能有效抵御病毒感染,可导致继发细菌感染。Objective To explore the level change of peripheral blood lymphocyte subgroup,the erythrocyte zinc and hs-CRP in children with hand-foot-mouth disease （HFMD）. Methods Children with severe HFMD in this hospital were selected as experimental group,and children in health that received physical examination in this hospital were selected as control group. Level of the peripheral blood lymphocyte subsets,erythrocyte zinc and hs-CRP were detected. Results In the HFMD group, total T cell percentage（CD3^＋ ）, auxiliary/induced T cells （CD3^＋ CD4^＋ ） percentage,inhibit/cytotoxic T cells（CD3^＋ CD8^＋ ） percentage.and the erythrocyte zinc levels were all significantly lower than that of the control group（P〈0.05） ,while the hs-CRP determination level,B cells （CD19^＋ ） percentage were significantly higher than those of the control group（P〈0.05）. Conclusion Children with severe HFMD have cellular immunity and hormone tmmunity function disorder and are lack of erythrocyte zinc. And their body cannot effectively resist infection virus, which can lead to secondary bacterial infection.

关 键 词：手足口病 淋巴细胞 红细胞锌 C-反应蛋白 

分 类 号：R725.1[医药卫生—儿科]