HIV/HBV合并感染者的CD_4^+T 淋巴细胞水平与肝功能及乙肝病毒复制水平的关系  

The Relationship between CD4^+ T Lymphocyte Level and Liver Function and Hepatitis B Virus Replication Level in the Patients of HIV/HBV co-Infectoin

作　　者：陈念[1] 蒋忠胜[1] 温小凤[1] 胡家光[1] 柯柳[1] 

机构地区：[1]广西柳州市人民医院感染病科,广西柳州545006

出　　处：《中国皮肤性病学杂志》2016年第1期47-49,共3页The Chinese Journal of Dermatovenereology

基　　金：广西自然科学基金资助课题(2013GXNSFAA0192123);广西卫生厅自筹课题(z2014410);柳州市应用技术研究与开发计划课题(2011J0302021);柳州市人民医院院内课题(lry201306)

摘　　要：目的了解人免疫缺陷病毒(HIV)/乙型肝炎病毒(HBV)合并感染者的CD_4^+T淋巴细胞与其基线肝功能和乙肝病毒复制水平(HBV DNA)的关系。方法对准备开始高效抗逆转录病毒治疗(HAART)的HIV/HBV合并感染患者69例进行基线CD_4^+T淋巴细胞、HBV DNA和肝功能检测。结果1.CD_4^+T淋巴细胞≤100个/μL组患者的天门冬氨酸氨基转移酶(AST)、HBV DNA显著高于CD_4^+T淋巴细胞>100个/μL组(P<0.05);CD_4^+T淋巴细胞≤100个/μL组患者的血清白蛋白(Alb)、凝血酶原活动度(PTA)显著低于CD_4^+T淋巴细胞>100个/μL组(P<0.05);两组血清总胆红素(TBI)、血清直接胆红素(DBI)、谷氨酸氨基转移酶(ALT)、血清球蛋白(Glo)差异无统计学意义(P>0.05)。2.CD_4^+T淋巴细胞计数水平与AST,HBV DNA,Alb,PTA的相关系数分别为(-0.314,-0.344,-0.35,0.333,P<0.05)。结论随着患者AIDS病情进展,HIV/HBV合并感染者的HBV DNA复制水平增高,肝功能损害进行性加重。Objective To investigate the relationship between CD4＋ T lymphocyte level and liver function and hepatitis B virus replication level in the patients of HIV/HBV co-infection. Methods The baseline HBV DNA, liver function and CD4＋ ＋ T lymphocytes were detected in 69 HIV/HBV co-infection patients who were going to receiving highly active antiretroviral therapy （HAART）. Results 1. The aspartate amino and HBV DNA of patients of 100/μL CEM ＋ T lymphocytes or less were significantly higher than those of patients of more than 100/μL CD4 ＋ T lymphoeytes was more than 100/μL. The serum albumin and prothromhin activity （PTA） of patients whose CD4 ＋ T lymphocytes was less than 100/μL were significantly lower than those of patients whose CD4 ＋ T lymphoeytes was more than 100/μL. Serum total bilirubin （TBIL） , serum direct bilirubin （DBIL）, alanine aminotransferase （ALT）, and serum immunoglobulin （G） showed no significant difference between these two group patients. The correlation coeffieients of AST, HBV DNA, Alb, and PTA with CD4＋ T lymphocyte level were respeetively -0. 314, -0. 344, 0. 35, and 0. 333. Conclusion With the development of AIDS, the level of HBV DNA replieation in patients with HIV/HBV eo-infeetion increased, and the liver funetion was progressively damaged.

关 键 词：人免疫缺陷病毒 乙型病毒性肝炎 高效抗逆转录治疗 

分 类 号：R512.91[医药卫生—内科学] R512.62[医药卫生—临床医学]