猪胚胎附植期免疫耐受机制的研究进展  

Progresses on Immune Tolerance Mechanism During Sow Embryo Implantation

作　　者：蒋尧[1] 张新颖[1] 樊自尧[1] 傅金銮[1] 王爱国[1] 

机构地区：[1]中国农业大学动物科技学院,北京100193

出　　处：《中国畜牧杂志》2016年第1期69-72,共4页Chinese Journal of Animal Science

基　　金：国家自然基金(31172176);国家现代农业产业技术体系(CARS-36)

摘　　要：猪胚胎附植是母胎间建立紧密联系的标志和首要环节。胚胎对于母体是一种同种异体移植物却未受到母体的免疫排斥,而成功附植和妊娠,说明母体对胚胎存在免疫耐受作用,母体建立免疫耐受是胚胎附植的关键过程,研究发现该过程受到辅助型T细胞、多种细胞因子、子宫局部免疫细胞以及其他生物活性物质的调控与影响。本文对胚胎附植期母胎间免疫耐受机制的研究进展进行综述。Implantation builds a strong link in maternal-fetal is the signs an d most important part of sows. As a allograft in maternal, the embryo has not been subjected maternal immune rejection. The success of implantation and pregnancy indicating that existence maternal immune tolerance. Maternal established the immune tolerance is the key processes of implantation which subjects to the control and influence of the T helper cell, A variety of cytokines, uterine local immune cells and other bioactive substance. Thisarticle reviews theresearch progress of immune toleranceon maternal-fetal interface during implantation.

关 键 词：胚胎附植 免疫耐受 辅助型T细胞 细胞因子 母猪 

分 类 号：S828.2[农业科学—畜牧学]