实时直接分析离子源-飞行时间质谱法快速筛查安非他明类物质  

Rapid Screening of Amphetamines by Time-of-Flight Mass Spectrometry Coupled with Direct Analysis in Real Time Ion Source

作　　者：连茹 吴忠平[2] 吕小宝[2] 汪蓉[2] 倪春芳[2] 张玉荣[2] 

机构地区：[1]中国医药工业研究总院上海医药工业研究院创新药物与制药工艺国家重点实验室,上海201203 [2]上海市公安局物证鉴定中心上海市现场物证重点实验室,上海200083

出　　处：《理化检验（化学分册）》2016年第1期1-6,共6页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：上海市科学技术委员会国内合作项目(13595810400)

摘　　要：采用实时直接分析(DART)离子源结合飞行时间质谱法(TOF-MS),提出了一种快速筛查毒品检材中安非他明类物质的方法。DART离子源温度400℃,栅极电压200V,进样速率0.4mm·s^(-1)。飞行时间质谱中选择正离子模式,孔1电压为30V和60V,分析8种安非他明类物质。通过得到的具有精确相对分子质量的准分子离子峰和两个以上的碎片离子峰建立筛查数据库,对检材中的安非他明类物质进行快速定性分析。8种安非他明类物质的检出限在0.05~0.1mg·L^(-1)之间。并分析了8种安非他明类物质在DART离子源下的裂解规律。A method for rapid screening of 8 amphetamines in drug samples was developed based on time of flight mass spectrometry （TOF-MS） coupled with direct analysis in real time （DART） ion source. Ion source temperature of 400 ℃, grid voltage of 200 V and the injection rate of 0. 4 mm .s -1 were adopted in DART, and positive ion mode and orificel voltages of 30, 60 V were adopted in TOF-MS for analysis of the 8 amphetamines. A screening database of accurate relative molecular mass of informative precursor ions and fragment ions was established for the rapid qualitative analysis of the 8 amphetamines in drug samples. The detection limits of the 8 amphetamines ranged from 0.05 to 0. 1 mg. L-1. The fragmentation regularity of the 8 amphetamines in DART ion source was analysized.

关 键 词：实时直接分析离子源 飞行时间质谱法 安非他明类物质 快速筛查 

分 类 号：O657.63[理学—分析化学]