探讨Gd-EOB-DTPA在磁共振胆道成像中的最佳延迟时间  

The optimal delay time of MR cholangiography with Gd-EOB-DTPA

作　　者：陈国勇[1] 唐鹤菡[1] 刘洋洋[1] 蔡磊[1] 刘曦娇[1] 宋彬[1] 

机构地区：[1]四川大学华西医院放射科,成都610041

出　　处：《放射学实践》2016年第1期30-34,共5页Radiologic Practice

基　　金：国家自然基金面上项目资助项目(81171338;81471658)

摘　　要：目的：探讨肝胆特异性对比剂Gd—EOB-DTPA在磁共振胆道成像中的最佳延迟时间。方法：采用轴面容积式内插值法屏气检查（VIBE）序列，对31例肝功能正常的志愿者行上腹部Gd—EOB-DTPA增强MRI动态扫描，获取5、10、15、20、25、30、40、50、60、70、80、90min轴面图像。测量胆道系统各部位（左肝管、右肝管、肝总管、胆囊、胆囊管及胆总管（近端、中段、远端））的信号强度（SI），计算相应时间点胆道系统各部位的信噪比（SNR）和对比噪声比（CNR），描绘其变化趋势曲线并记录达峰时间点。采用Likert5级评分法分别评价各个时间点左右肝管一二级分支、肝总管、胆囊、胆囊管及胆总管的可视性。结果：胆囊的SI、sNR、CNR的达峰时间均为70～80min；左右肝管、肝总管、胆囊管及胆总管（近端、中段、远端）SI出现峰值的时间为40～50min，SNR出现峰值的时间为50～60min；胆囊管、左右肝管、肝总管及胆总管近端cNR出现峰值的时间为30～40min，胆总管中段和远端cNR出现峰值的时间为60～70min。结论：肝功能正常成人胆囊最佳延迟时间为注射Gd-EOBDTPA后80min，左右肝管、肝总管、胆囊管及胆总管的最佳延迟强化时间为40～60min。Objective：To investigate the optimal delay time of MR cholangiography （MRCP） with hepato-bitiary spe- cific contrast Gd-EOB-DTPA. Methods： 31 volunteers with normal liver function were recruited. MRCP was performed with axial volumetric interpolated breath hold examination （VIBE） sequence after injection of Gd-EOB-DTPA,the axial images were acquired in 5,10,15,20,25,30,40,50,60,70,80,90 minutes. The signal intensities （SI） of different position of biliary tract including left hepatic duct. right hepatic duct. common hepatic duct. gallbladder, cystic duct and common bile duct （proximal, middle,distal） were measured. The signal to noise ratio （SNR）, contrast to noise ratio （CNR） wre calciulated. The time-intesity curve （TIC） and the corresponding time to peak （TTP） in each part of the biliary system were recorded The visibility of secondary branches of left and right hepatic ducts, common hepatic duct, gallbladder, cystic duct and com- mon bile duct at each time point was evaluated by Likert scale. Results： The TTP of SI, SNR and CNR of gallhladder was 70~80 minutes respectively;of left hepatic duct, right hepatic duct, common hepatic duct, cystic duct and common bile duct （proximal,middle and distal） was 40~50 minutes respectively,and TTP of SNR was 80~60 minutes. The TTP of CNR in cystic duct,left and right hepatic duct,hepatic duct and proximal common bile duct was 30~40 minutes respectively,while in the middle and distal part of common bile duct was 60~70 minutes respectively. Conclusion： In adults with normal liver function,the optimal delay time of gallbladder is 80 minutes after injecting Gd-EOB-DTPA,of bile duct is 40~60 minutes.

关 键 词：磁共振成像 磁共振胆道成像 Gd—EOB-DTPA 最佳延迟时间 

分 类 号：R445.2[医药卫生—影像医学与核医学] R575.7[医药卫生—诊断学]