五参口服液对气阴两虚型室性期前收缩心率变异性影响的临床研究  

Clinical research of “Five Shen Oral Liquid ” influence on the Qi Yin deficiency premature ventricular contractions' heart rate variability

作　　者：张一乐[1] 史苗颜[1] 徐燕[2] 

机构地区：[1]上海中医药大学附属曙光医院呼吸科,上海201203 [2]上海中医药大学附属曙光医院心内科,上海201203

出　　处：《上海中医药杂志》2016年第1期45-47,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市科委上海中医临床重点实验室项目(14DZ2273200)

摘　　要：目的观察五参口服液联合西药治疗气阴两虚型室性期前收缩的临床疗效。方法将60例气阴两虚型室性早搏患者随机分为治疗组与对照组,每组30例。两组均予常规西药治疗,对照组加用生脉口服液,治疗组加用五参口服液。两组疗程均为30天,观察比较室性早搏发作次数、中医证候积分及心率变异性参数的变化情况。结果 1治疗前后组内比较,两组心电图、24 h动态心电图室性早搏次数均明显减少,差异有统计学意义(P<0.05);组间治疗后比较,ECG、DCG室性早搏次数差异均有统计学意义(P<0.05)。2组间治疗后比较,中医证候积分差异有统计学意义,治疗组优于对照组(P<0.05)。3组间治疗后比较,SDNN、SDANN、SDNNIDX、r MSSD水平差异有统计学意义,治疗组优于对照组(P<0.05)。结论五参口服液联合西药治疗气阴两虚型室性期前收缩的疗效满意,可显著缓解患者的临床症状及体征,其机制可能与调控交感及迷走神经间的相对平衡有关。Objective To observe clinical efficacy of＂Five Shen Oral Liquid＂combined with western medicine in the treatment of Qi Yin deficiency premature ventricular contractions（ VPCs）. Methods 60 cases of Qi Yin deficiency VPCs patients were randomly divided into treatment group and control group,30 cases in each group. The two groups were both treated with conventional western medicine,the control group was treated with＂Sheng Mai Oral Liquid＂in addition,and the treatment group was treated with＂Five Shen Oral Liquid＂in addition. Two groups of treatment for 30 days,observe the comparison of the number of VPCs,TCM syndrome differentiation and the change of heart rate variability parameters. Results 1Before and after the treatment,the number of VPCs of both electro cadiogram and 24 h dynamic electrocadiogram in the two groups were significantly decreased,the difference was statistically significant（ P 〈 0. 05）. After treatment,there were significant differences in VPCs of both DCG and ECG between the two groups（ P 〈 0. 05）. 2 After treatment,the difference of TCM syndrome differentiation was statistically significant,and the treatment group was better than the control group（ P 〈 0. 05）. 3After treatment,SDNN,SDNNIDX,SDANN and r MSSD levels were significantly different between the two groups,the treatment group was better than the control group（ P 〈 0. 05）. Conclusion The effectiveness of the＂Five Shen Oral Liquid＂combined with western medicine in the treatment of Qi Yin deficiency VPCs was satisfied,it can significantly ease the patient’s clinical symptoms and signs,the mechanism might be related to the regulation of the sympathetic and vagal nerve relative balance.

关 键 词：心律失常 室性早搏 心悸 气阴两虚证 五参口服液 心率变异性 

分 类 号：R259[医药卫生—中西医结合]