空腹血糖与冠状动脉狭窄在老年人群的相关性研究  

Study on the relationship between fasting blood glucose and coronary artery lesion in the elderly

作　　者：张维[1] 吴毓敏[2] 韩维嘉[3] 刘千军[1] 郭新贵[1] 

机构地区：[1]复旦大学附属华东医院心内科,上海市200040 [2]复旦大学附属华东医院肾内科 [3]复旦大学附属华东医院营养科

出　　处：《老年医学与保健》2015年第6期366-368,379,共4页Geriatrics & Health Care

摘　　要：目的了解不同空腹血糖水平与老年冠脉病变的关系。方法回顾分析2013年1月--12月之间年龄在60岁及以上因胸闷胸痛人院并行冠状动脉造影者的相关临床资料和冠脉造影结果。按空腹痂_糖值（FPG）分成3组：空腹血糖正常组（NGT组）、空腹血糖受损组（IFG组）和糖尿病组（DM组），应用冠脉病变支数和Gensini评分对3组患者进行冠状动脉病变程度的评价。同时将一般临床资料、生化指标、冠状动脉造影资料比较，并分析各组冠状动脉病变严重程度相关的危险因素。结果（1）DM组的低密度脂蛋白（LDL）显著高于NGT组和IFG组（P〈0．05）；性别、年龄、高血压、BMI、吸烟、高密度脂蛋白、胆固醇和三酰甘油在3组间的差异均无统计学意义（P〉0．05）；（2）3组间冠脉狭窄严重程度比较，IFG组和DM组冠心病患者冠脉狭窄Gensini评分高于NGT组，且冠脉以双支或三支病变为主（P〈0．05）；（3）多因素线性逐步回归显示LDL、BMI和FPG与Gensini评分独立相关（P〈0．05）。结论空腹血糖异常增高可能是老年冠心病冠脉病变严重的危险因素。Objective To study the relationship between the level of fasting blood glucose and coronary artery lesion in the elderly. Methods The clinical data and the coronary angiography results of older patients who hospitalized from Jan- uary to December 2013 with chest pain and underwent coronary angiography were retrospectively reviewed. The patients were classified into 3 groups based on glucose level, normal fasting blood glucose group （NGT group）, impaired fasting glucose group （IFG group）, and diabetes mellitus group （DM group）. The number of coronary arterystenosis and Gensini score were used to evaluate the severity of coronary artery disease in 3 groups. The general clinical data, biochemical para- meters and coronary angiography results were compared, and the risk factors for coronary artery lesions severity of 3 groups were analyzed. Results （1） LDL of DM group was significantly higher than both NGT group and IFG group （P 〈 0.05）; There were no statistical differences in gender, age, hypertension, BMI, smoking history, HDL, TG and TCH in 3 groups （P〉0.05）. （2） IFG group and DM group had higher Gensini score than NGT group, and had 2 or 3 stenosed coronary vessels （P〈0.05）. （3） Linear stepwise regression analysis showed that LDL, BMI, FPG and Gensini Score were independent factors for coronary artery disease severity （P〈0.05）. Conclusion The higher fasting blood glucose was risk factor for coronary artery disease severity.

关 键 词：老年 空腹血糖 冠状动脉造影 GENSINI评分 

分 类 号：R587.1[医药卫生—内分泌]