C-反应蛋白与白细胞介素-8联合检测在新生儿细菌性感染诊断与治疗中的应用价值  被引量:2

Application of C-reactive protein and interleukin-8 in diagnosis and treatment of neonatal bacterial infections

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作  者:谭静[1] 马洪梅[1] 姚毅[1] 

机构地区:[1]达州市中心医院儿科,四川达州635000

出  处:《西部医学》2016年第1期95-98,共4页Medical Journal of West China

基  金:四川省科技厅支撑计划项目(2014SZ00055)

摘  要:目的探讨C-反应蛋白(CRP)联合白细胞介素-8(IL-8)在新生儿细菌性感染中的意义,为抗生素临床应用提供参考。方法选取在儿科接受治疗的细菌性感染新生儿114例作为研究,根据感染状况分感染组61例和可疑组53例,同时在应用抗生素治疗的时候,按照抗生素应用标准不同分为经验组和联合组,再选取无细菌感染新生儿48例作对照组,在研究前、研究1、2周后采用ELLSA检测感染患儿血清中IL-8含量和免疫比浊法检测CRP含量。结果研究前,感染组和可疑组IL-8、CRP显著高于对照组(P<0.01),感染组显著高于可疑组,差异具有统计学意义(P<0.01),与研究前相比,研究1、2周后,可疑组和感染组均存在变化,差异具有统计学意义(P<0.01);研究前感染组和可疑组患者体内IL-8和CRP存在相关性(r=0.916,P<0.01);可疑感染患者中,研究前、研究1周后,联合组和经验组抗生素应用差异无统计学意义(P>0.05),研究2周后,差异显著,具有统计学意义(2=7.209,P=0.007<0.01);临床感染患者中,研究前、研究1周后,经验组和联合组抗生素应用差异无统计学意义(P>0.05),研究2周后,差异具有统计学意义(2=5.504,P=0.019<0.01)。结论 C-反应蛋白联合白细胞介素-8对新生儿细菌性感染具有诊断意义,且依据CRP和IL-8联用的一定标准可以减少抗生素应用,可在临床推广应用。Objective To explore C- reactive protein and interleukin -8 in bacterial infection in neonate and provide guidance for the application of antibiotics. Methods 114 newborns with bacterial infection were divided into infection group (61 cases) and suspected infection group (53 cases), according to the infection status. The patients were divided into experience group and combination group and controlled with 48 newborns without infection. The serum IL-8 and CRP were detected before the study, 1 and 2 weeks after study. Results Before the study, IL-8 and CRP of infection group and suspected infection group were significantly higher than that of the control group (P〈0.01). IL-8 and CRP of infection group were significantly higher than that suspected infection group (P〈0.01). IL-8 and CRP of infection group and suspected infection group of 1 week and 2 weeks after study were different from that before study (P〈0.01). There was relationship between IL-8 and CRP of infection group and suspected infection group before study (r=0. 916, P〈 0.01). The application of antibiotics of experience group and combination group was not different before study and 1 week after study (P〉0.05) and was different 2 week after study (X2 = 5. 504,P=0.19〈0.01). Conclusion C- reac- tive protein and interleukin -8 in neonatal bacterial infection plays a role in diagnosis. CRP combined with IL-8 can reduce the use of antibiotics.

关 键 词:CRP IL-8 新生儿细菌性感染 抗生素 

分 类 号:R722.13[医药卫生—儿科]

 

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