暴发性1型糖尿病7例并文献复习  

Seven case of fulminant type 1 diabetes and review of literature

作　　者：钟宇华[1] 廖伟玲[1] 苏会璇[1] 邱俊霖[1] 彭丽华[1] 

机构地区：[1]广西医科大学第九附属医院内分泌代谢科,广西北海536000

出　　处：《临床荟萃》2016年第1期100-102,共3页Clinical Focus

基　　金：北海市科学技术局基金资助项目(北科合201303008);广西卫计委课题(82015016)

摘　　要：目的探讨中国暴发性1型糖尿病的临床特点,并与日、韩两国进行比较。方法纳入我国暴发性1型糖尿病患者52例,日本患者161例,韩国患者29例,总结其临床特点。结果 1我国暴发性1型糖尿病患者平均发病年龄为（32.4±12.6）岁,18岁以上患者约占总数的96%,而且18～30岁的病例数最多,约占总数的52%。2与日本相比,我国暴发性1型糖尿病患者发病年龄更低[（32.4±12.6）岁vs（39.14±15.7）岁,P〈0.05]、病程更短（3.4±2.3天vs 4.44±3.1天,P〈0.05）、发病时血糖较低[（38.5±15.3）mmol/L vs（44.2±20.0）mmol/L,P〈0.05];电解质代谢紊乱更严重,表现为高血钾[（6.3±1.2）mmol/L vs（5.5±1.2）mmol/L,P〈0.05],低血钠[（128.9±6.2）mmol/L vs（131.0±9.0）mmol/L,P〈0.05]。3与韩国相比,我国暴发性1型糖尿病患者发病年龄更低[（32.4±12.6）岁vs（37.4±12.4）岁,P〈0.05],起病时血钾高于韩国[（6.3±1.2mmol/L vs（5.6±1.5）mmol/L,P〈0.05]。结论1暴发性1型糖尿病在我国并非罕见,且患者多以成年起病。2中国暴发性1型糖尿病患者较日本、韩国发病年龄小,发病时血钾更高。Objective To study the clinical characteristics of Chinese fulminant type 1diabetes and understand China fulminant type 1diabetes clinical characteristics with Japanese,Korean whether there is a difference between the two countries.Methods Analysis of clinical data of 52 patients with fulminant type 1diabetes in China,and to study the difference between Chinese and Japanese patients.Results 1Patients with fulminant type 1diabetes in China the average age was（32.2±12.6）years old,at least 18 years of age accounted for about 96% of the total number of patients,and the maximum number of 18 to 30years old,about 52% of the total.2Compared with those of Japanese patients with fulminant type 1diabetes in our country the onset age of the lower（32.4±12.6years vs 39.14±15.7years,P 〈0.05）,shorter duration（3.4±2.3days vs 4.44±3.1days,P 〈0.05）,the low blood sugar（38.5±15.3mmol/L vs 44.2±20.0 mmol/L,P 〈0.05）;Electrolyte metabolism disorder is more serious,characterized by high potassium,low serum sodium（6.3±1.2mmol/L vs 5.5±1.2mmol/L,128.9±6.2vs 131.0±9.0mmol/L,P 〈0.05）.3Compared with south Korean patients,the onset age of China is lower（32.4±12.6years vs 37.4±12.4years）,and the onset of potassium is higher（6.3±1.2mmol/L vs 5.6±1.5mmol/L,P 〈0.05）.Conclusion 1 Fulminant type 1diabetes is not rare in our country,and patients with adult onset.2 Compared with Japan,South Korea,the Chinese patients have the lower age of onset and higher serum potassium.

关 键 词：糖尿病 1型 发病年龄 高钾血症 

分 类 号：R587.1[医药卫生—内分泌]