多氧霉素及其生物合成的研究进展  

Research progress on polyoxins and its biosynthesis

作　　者：王季季 邓子新[1,2] 陈文青[1] 

机构地区：[1]武汉大学药学院组合生物合成与新药发现(教育部)重点实验室,湖北武汉430071 [2]上海交通大学生命科学与生物技术学院微生物代谢国家重点实验室,上海200030

出　　处：《微生物学通报》2016年第1期205-210,共6页Microbiology China

摘　　要：多氧霉素(Polyoxins)是高效广谱抗真菌核苷类抗生素,在农业上广泛用于防治植物真菌病害。本文综述了多氧霉素化学结构和理化性质,尤其是武汉大学组合生物合成与新药发现(教育部)重点实验室近年来在该抗生素生物合成基因簇的克隆、生物合成途径的阐明以及多氧霉素组合生物合成等多个方面的研究进展与成果,并对今后以多氧霉素为代表的核苷类抗生素的生物合成研究进行了展望。Polyoxin is a high effective and broad-spectrum antifungal peptidyl nucleoside antibiotics inhibiting fungal cell wall biosynthesis, as a result, it was used extensively to control phytopathengenic fungi in agriculture. This review summarized the research progress on the chemical structure and physical and chemical properties of this antibiotic, and particularly described recent advance of our lab on the cloning and elucidation of the polyoxin biosynthetic pathway, as well as the combinatorial biosynthesis of this antibiotic. Simultaneously, we also take a brief perspective on the studies on nucleoside antibiotics biosynthesis.

关 键 词：多氧霉素 核苷类抗生素 生物合成途径 组合生物合成 

分 类 号：TQ455[化学工程—农药化工]