绝经后女性2型糖尿病合并高尿酸血症的相关因素研究  

Factors associated with hyperuricemia in postmenopausal women with type 2 diabetes mellitus

作　　者：陈海兰[1] 高宇[2] 葛晓春[2] 李丽慧[2] 冯增斌[3] 王英南[2] 刘晓燕[2] 

机构地区：[1]解放军第二六六医院内分泌科,承德067000 [2]承德医学院附属医院内分泌科 [3]承德医学院附属医院心脏血管疝外科

出　　处：《中华老年心脑血管病杂志》2016年第1期25-27,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：河北省卫生厅科研基金项目(20130022)

摘　　要：目的探讨绝经后女性2型糖尿病(T2DM)患者合并高尿酸血症(HUA)的相关因素。方法选取绝经后女性T2DM患者365例,依据女性血尿酸是否≥360μmol/L,分为正常尿酸(NUA)组316例和HUA组49例。分析2组临床相关指标及糖尿病慢性并发症和合并症的差异。结果与NUA组比较,HUA组糖尿病视网膜病变(61.2%vs 45.6%)、糖尿病肾病(67.3%vs 12.3%)、颈动脉粥样硬化斑块(65.3%vs 44.9%)、高血压(73.5%vs52.5%)、冠心病(34.7%vs 18.7%)及脂肪肝(61.2%vs 47.5%)的发病率明显升高(P<0.05,P<0.01)。多元线性回归分析显示,糖化血红蛋白(β=-0.207,P=0.026)、糖尿病病程(β=0.166,P=0.018)、LDL-C(β=0.184,P=0.009)、肌酐(β=0.356,P=0.002)是HUA的独立影响因素。结论绝经后女性T2DM合并HUA患者有较高的大小血管并发症的发生率。Objective To study the factors associated with hyperuricemia in postmenopausal women with type 2diabetes mellitus（T2DM）.Methods Three hundred and sixty-five postmenopausal T2 DM women were divided into normal serum uric acid（NUA）group（n=316）and hyperuricemia（HUA）group（n=49）.Their renal function and diabetic chronic complications were detected.Results The incidence of diabetic retinopathy,diabetic nephropathy,carotid atherosclerotic plaques,hypertension,coronary heart disease and fatty liver was significantly higher in HUA group than in NUA group（61.2% vs 45.6%,67.3% vs 12.3%,65.3% vs 44.9%,73.5% vs52.5%,34.7%vs 18.7%,61.2% vs 47.5%,P〈0.05,P〈0.01）.Multivariate linear regression analysis showed that HbA1 C,disease duration,serum LDL-C and Cr level were the independent risk factors for hyperuricemia（β=-0.207,P=0.026;β=0.166,P=0.018;β=0.184,P=0.009;β=0.356,P=0.002）.Conclusion The incidence of diabetic microvascular and macrovascular complications is high in postmenopausal T2 DM women with HUA.

关 键 词：绝经后期 糖尿病 2型 高尿酸血症 尿酸 糖尿病视网膜病变 糖尿病肾病 颈动脉疾病 高血压 

分 类 号：R587.2[医药卫生—内分泌] R589.7[医药卫生—内科学]