中空介孔二氧化硅纳米材料(HMSNs)的合成及其生物相容性  

Synthesis of Hollow Mesoporous Silica Nanoparticles and Its Biocompatibility

作　　者：郑昆[1] 杨红[2] 温刚[1] 张元新[1] 葛雅琨[1] 隋新[1] 

机构地区：[1]吉林化工学院生物与食品工程学院,吉林吉林132022 [2]吉林工贸学校,吉林吉林132021

出　　处：《吉林大学学报（理学版）》2016年第1期148-151,共4页Journal of Jilin University:Science Edition

基　　金：国家自然科学基金(批准号:50573030)

摘　　要：以CaCO_3为模板合成中空介孔二氧化硅纳米材料(HMSNs),并通过透射电镜(TEM)和小角X射线粉末衍射(SAXRD)对样品进行表征,通过流式细胞仪检测HMSNs样品对A549的细胞内吞能力及生物相容性.结果表明:CaCO_3-HMSNs是以CaCO_3为核,介孔二氧化硅为壳的纳米粒子;当材料的质量浓度为62.5μg/mL时,细胞的存活率为100%;有92.80%的细胞吸收了样品HMSNs,即HMSNs具有较高的细胞内吞能力及生物相容性.We used CaCO3 as a template to synthesize hollow mesoporous silica nanoparticles（HMSNs）,and characterized the samples by means of transmission electron microscope（TEM）and small angle X-ray diffraction（SAXRD）.The in vitro biocompatibility and endocytosis properties of HMSNs were detected on A549 cells by flow cytometry.The results show that CaCO3-HMSNs is the nanopartocles,where CaCO3 is the core and mesoporous silica is the shell;the survival rate of the cells is 100% when the mass concentration of HMSNs is 62.5μg/mL;the HMSNs materials are absorbed by 92.80% of A549.That is,the HMSNs has a higher endocytosis and biocompatibility.

关 键 词：中空介孔二氧化硅纳米材料 生物相容性 细胞内吞作用 

分 类 号：O613.72[理学—无机化学]