还原氧化石墨烯-硫化铜纳米复合材料的制备及在癌症热疗中的应用  

Preparation of Reduced Graphene Oxide-Copper Sulfide Composite as Efficient Photothermal Agents for Ablation of Cancer

作　　者：孔祥权[1] 严刚[1] 邝淼[1] 容建华[1] 

机构地区：[1]暨南大学材料科学与工程系,广州510632

出　　处：《高等学校化学学报》2016年第1期1-6,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21344001)资助~~

摘　　要：通过一步水热法制备了一种具有光热性能的纳米复合材料——还原氧化石墨烯-硫化铜(rGO-CuS),利用傅里叶变换红外光谱、拉曼光谱、紫外-可见光谱及高分辨透射电子显微镜对所合成纳米复合物的结构和形貌进行了表征,并通过细胞实验和动物实验考察其癌症热疗效果.结果表明,与未复合的氧化石墨烯(GO)和硫化铜相比,rGO-CuS在近红外光区域具有更高效的光热转换效率;rGO-CuS的光热治疗效果明显好于GO和CuS.A novel reduced graphene oxide-copper sulfide nanoplates（ rGO-CuS） composite with photothermal property was synthesized via one-pot hydrothermal method. Structure and morphology of the as-synthesized r GO-CuS nanocomposite were confirmed by transmission electron microscopy（TEM）,UV-Vis-NIR and Raman spectroscopy. The rGO-CuS nanocomposite showed enhanced optical absorbance in near infrared region and higher photothermal conversion efficiency than graphene oxide（GO） and CuS nanoplates. The rGO-CuS nanocomposite was further used to photothermal ablation of cancer cells and cancer tissue under a 980 nm laser irradiation and showed improved performance than CuS nanoplates and GO.

关 键 词：氧化石墨烯 硫化铜 纳米复合材料 光热治疗 癌细胞 

分 类 号：O614.12[理学—无机化学]