氟比洛芬酯对骨科手术超前镇痛及术后镇痛的临床疗效评价  

Clinical effect of flurbiprofen axetil injection on preemptive and postoperative analgesia in orthopedic surgery patients

作　　者：贾秀眉[1] 兰丽琴[1] 汤礼贵[1] 

机构地区：[1]瑞安市人民医院护理部,浙江瑞安325200

出　　处：《中国临床药理学杂志》2016年第2期150-152,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察氟比洛芬酯注射液对骨科手术超前镇痛及术后镇痛的临床疗效。方法 78例骨科手术治疗的患者随机分为试验组39例和对照组39例。对照组患者麻醉前15 min静脉注射帕瑞昔布钠20 mg(10 m L);使用丙泊酚1~2mg·kg^(-1)诱导麻醉,术中使用异氟烷维持麻醉;术后将帕瑞昔布钠60 mg加0.9%氯化钠配至100 m L,静脉滴注。试验组患者麻醉前15 min静脉注射氟比洛芬酯50 mg;使用丙泊酚1~2 mg·kg^(-1)诱导麻醉,术中使用异氟烷维持麻醉;术后将氟比洛芬酯50 mg加0.9%氯化钠配至100 m L,静脉滴注。记录患者术前或术后的平均动脉压、心率、视觉模拟评分(VAS)、Ramsay镇静评分(RSS)以及前列腺素E2(PGE2)、血清C反应蛋白(CRP)含量;同时统计2组的不良反应发生率。结果除术后即刻的VAS评分试验组低于对照组外(P<0.05),2组患者的平均动脉压和心率、VAS、RSS差异均无统计学意义。试验组术后24 h的血清CRP含量为(16.77±5.52)mg·L^(-1),显著低于对照组的(20.68±7.76)mg·L^(-1)(P<0.05);试验组术后24 h的血清PGE2含量与对照组差异无统计学意义(135.1 vs 141.6 pg·mL^(-1),P>0.05)。试验组的不良反应发生率显著低于对照组(7.7%vs 20.5%,P<0.05)。结论氟比洛芬酯注射液用于骨科手术患者镇痛效果较好,减轻患者的应激反应,减少不良反应发生率。Objective To determine the analgesic effects of flurbiprofen axetil injection on orthopedic surgery patients. Methods Seventy- eight orthopedic surgery patients were randomly divided into control group（ n = 39） and test group（ n = 39）. Patients in control group were given intravenous administration of parecoxib 20 mg at 15 min before anaesthesia induced by propofol 1- 2 mg·kg^-1and maintained by isoflurane in operation; after operation,60 mg of parecoxib dissolved in 100 mL0. 9% Na Cl was intravenously dripped. Patients in test group were given the same treatment beside the 20 mg of parecoxib was changed to 50 mg of flurbiprofen axetil. Average artery pressure（ MAP） and heart rate（ HR）,visual analogue score（ VAS）,Ramsay sedation score（ RSS）,levels of serum C reactive protein（ CRP）,prostaglandin E2（ PGE2）and incidence of adverse drug reactions of the two groups were observed.Results The MAP and HR,VAS,RSS of two groups showed no statistical significance expect the VAS at moment post surgery; the content ofserum CRP in test group at postoperative 24 h was（ 16. 77 ± 5. 52） mg·L^-1,significantly lower than that of control group of（ 20. 68 ± 7. 76） mg ·L^-1（ P〈0. 05）; the PGE2 content in test group had no significant difference with control group（ 135. 1 vs 141. 6 pg ·mL^-1,P〉0. 05）. The incidence of adverse drug reaction in test group was significantly lower than that in control group（ 7. 7% vs 20. 5%,P〈0. 05）. Conclusion Flurbiprofen axetil injection can reduce the stress reaction of orthopedic surgery patients,the incidence of side effect was also lower.

关 键 词：氟比洛芬酯 骨科手术 镇痛 C反应蛋白 前列腺素E2 

分 类 号：R687.3[医药卫生—骨科学] R971.1[医药卫生—外科学]