生长激素释放肽和瘦素与进展期胃癌低蛋白血症的关系  

Relationship between the levels of ghrelin and leptin and the hypoalbuminemia of advanced gastric carcinoma

作　　者：王海鹏[1] 朱袭嘉[1] 王丽兰[1] 田小林[1] 何永玲[1] 庞凌坤[1] 戴凌[1] 陈霄[1] 

机构地区：[1]桂林医学院附属医院胃肠外科,桂林541001

出　　处：《中国临床药理学杂志》2016年第2期180-182,共3页The Chinese Journal of Clinical Pharmacology

基　　金：桂林市科学研究与技术开发计划基金资助项目(20120121-1-10)

摘　　要：目的观察胃癌患者血清生长激素释放肽(ghrelin)和瘦素(leptin)水平与进展期胃癌低蛋白血症的关系及临床病理学意义。方法用放射免疫分析法(RIA)和酶联免疫吸附法(ELISA)测定20例健康受试者(正常组)和低蛋白血症者37例(试验组,白蛋白<35 g·L^(-1))和蛋白正常者88例(对照组,白蛋白≥35 g·L^(-1))的血清生长激素释放肽和瘦素水平的变化,并检测其与临床病理学参数的关联性。结果试验组和对照组血清生长激素释放肽和瘦素水平均显著高于正常组(P<0.01);试验组血清生长激素释放肽和瘦素水平显著高于对照组。血清生长激素释放肽和瘦素高含量患者中,低分化癌和淋巴结转移患者的比例较高。结论胃癌患者血清生长激素释放肽和瘦素水平的变化对胃癌诊断和预后具有重要的临床价值,为癌性低蛋白血症的诊治提供理论依据。Objective To discuss the relationship between the level of ghrelin and leptin of patients with gastric carcinoma and the hypoalbuminemia of advanced gastric carcinoma,and its significance of clinical pathology as well. Methods Radioimmunoassay（ RIA） and enzyme linked immunosorbent assay（ ELISA） were used to determine the changes of the ghrelin and leptin level in 20 cases of normal healthy people and120 patients with gastric cancer（ including 37 cases of hypoalbuminemia（ albumin 35 g·L^-1） and 88 cases of normal protein people（ albumin≥35 g·L^-1）,their expressions and the relevance of clinical pathology parameters were also detected. Results The ghrelin and leptin levels of patients with gastric carcinoma were significantly higher than those of normal group（ P 〈0. 01）,and the ghrelin and leptin levels of patients with the hypoalbuminemia were obviously higher than those of health subjects with normal protein. In addition,in patients with high content of ghrelin and leptin,the rate of patients with poorly differentiated carcinoma and lymph node metastasis was obviously increased. Conclusion The detection of the changes of ghrelin and leptin levels will be of great significance in the diagnosis and prognosis of gastric carcinoma,which provides theoretical basis for the diagnosis and treatment of cancerous hypoalbuminemia.

关 键 词：进展期胃癌 生长激素释放肽 瘦素 低蛋白血症 

分 类 号：R735.2[医药卫生—肿瘤]