海螵蛸气流粉碎工艺优化及粉碎前后相关指标对比  

Optimization of fluid jet pulverizing process for cuttlebone and comparison of related indices before and after pulverization

作　　者：张爱丽[1] 徐忠坤[2,3] 张庆芬[2,3] 徐连明[2,3] 

机构地区：[1]江苏联合职业技术学院连云港中医药分院,江苏连云港222007 [2]江苏康缘药业股份有限公司,江苏连云港222001 [3]中药制药过程新技术国家重点实验室,江苏连云港222001

出　　处：《中成药》2016年第1期58-62,共5页Chinese Traditional Patent Medicine

基　　金：国家"重大新药创制"科技重大专项(2013ZX09402203)

摘　　要：目的对海螵蛸(金乌贼Sepia esculenta Hoyle)气流超微粉碎和普通粉碎的相关指标进行对比和工艺优化。方法以超微粉的粒径D50为中心复合法的指标,对粉碎压力、进料压力、螺旋进料速度进行多元线性回归和二项式拟合,并用响应优化器优化实验结果。采用酸碱滴定法,对两种粉体的制酸性能进行比较。结果最佳粉碎工艺为粉碎压力0.77 MPa,进料压力0.62 MPa,螺旋进料速度227.0 r/min;超微粉的D506.60μm,明显小于普通粉,超微粉的S/V 12 231.490 m^2/cm^3,明显大于普通粉。1.0 g超微粉能中和人工胃酸62.50 m L,与普通粉差别不大,但反应时间缩短。结论用Minitab优化方案制得的超微粉与模型预测值基本一致,而且其制酸效果优于普通粉体。AIM To optimize the fluid jet pulverizing process for cuttlebone（ Sepia esculenta Hoyle） and compare the related indices of normal ground powder and micronized powder before and after pulverization. METHODS Central composite design was employed. With the particle diameter of micronized powder D50 as an index,crushing pressure,feed pressure and feed speed were used for fitting the multiple linear regression and binomial equation. The experimental result was screened by response optimizer. The ability of neutralizing gastric acid of the normal ground powder and micronized powder was then assessed by acid-base titration method. RESULTS The good parameters were determined to be 0. 77 MPa for crushing pressure, 0. 62 MPa for feed pressure and227. 0 r / min for feed speed. The micronized powder,at a particle diameter of 6. 60 μm,was significantly smaller than that of normal ground powder. S / V with a value of 12 231. 490 m^2/ cm^3 was significantly bigger than that of the normal ground powder. 1. 0 g micronized cuttlebone powder neutralized 62. 11 m L gastric acid,demonstrating no much difference with normal groud powder,but a shorter reaction time. CONCLUSION Under the conditions optimized by Minitab,the obtained micronized powder is basically identical to the predictive model,and it is superior to that of the normal ground powder in terms of its neutralizing effect on gastric acid.

关 键 词：海螵蛸 气流粉碎 中心复合法 粒径 制酸性能 

分 类 号：R284[医药卫生—中药学]