自然唾液中介孔生物活性玻璃诱导牙釉质仿生再矿化研究  

Bionic Remineralization of Acidic Etched Enamel Induced by Using Mesoporous Bioactive Glass in Natural Oral Saliva

作　　者：董志红[1] 聂志萍[1] 周长春[2] 

机构地区：[1]成都大学机械工程学院,成都610106 [2]四川大学国家生物医学工程研究中心,成都610064

出　　处：《无机材料学报》2016年第1期88-94,共7页Journal of Inorganic Materials

基　　金：国家自然科学基金(81201475)~~

摘　　要：将介孔生物活性玻璃用于修复酸蚀的牙釉质,样品经模拟刷牙后,浸泡在自然唾液中。通过X射线衍射(XRD)、扫描电镜(SEM)、聚焦离子束(FIB)切割后透射电镜(TEM)观察、X射线能谱分析(EDX)、选区电子衍射(SAED)分析,及纳米压痕力学测试等表征显示,经过介孔生物活性玻璃处理后的牙釉质,在唾液中浸泡6 h,牙釉质表面形成棒状类骨磷灰石;浸泡24 h,表面形成均匀矿化层,厚度约为100 nm,且和牙釉质基体结合紧密,钙磷比接近牙釉质基体。矿化层在300μN作用下,出现划痕爆破值,其显微力学性能为(3.37±0.62)GPa,弹性模量为(60.48±4.56)GPa,均达到未酸蚀牙釉质的75%。实验结果表明,介孔生物活性玻璃可较快地诱导矿化,有望用于酸蚀牙釉质修复及早期龋齿的预防。Acidic etched enamel was treated with mesoporous bioactive glass （M58S） to induce enamel reminer- alization in natural oral saliva. By simulated brushing teeth, the M58S was adhered on the enamel surface. Then the samples were rinsed by water and immersed in natural oral saliva for different periods. Characterized by XRD, SEM, FIB-TEM, EDX, SAED, and nanoindentation, the samples showed that a new mineralized phase appeared on the surface of the treated samples after soaking for 6 h. After soaking for 24 h, a compact and homogeneous miner- alized layer at the thickness of about 100 nm formed with similar structure to apatite, and ratio of calcium to phos- phate which was close to the enamel＇s. Under pressure of 300 μN, mineralized layer showed a scratch limited value with microhardness at （3.37±0.62） GPa and elastic modulus at （60.48±4.56） GPa, both close to 75% value of origi- nal enamel. These results indicate that mesoporous bioactive glass can rapidly repair etched enamel and prevent teeth from caries. Therefore, the mesoporous bioactive glass may be used as bionic remineralization materials.

关 键 词：牙釉质 介孔生物活性玻璃 再矿化 

分 类 号：TQ174[化学工程—陶瓷工业]