平胃散中药物炮制前后药效学比较  

Comparative Study on Pharmacodynamics of Pingwei San with Different Raw Material

作　　者：张美[1] 龚晓猛 熊瑞[1] 崔园园[1] 陈志敏[1] 李文兵 胡昌江[1] 

机构地区：[1]成都中医药大学药学院,成都611137 [2]四川新绿色药业科技发展股份有限公司,成都611930

出　　处：《中国实验方剂学杂志》2016年第2期17-20,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：四川省科技厅"突破性川产道地药材新品种选育"项目(2011NZ0098-12-06)

摘　　要：目的:针对平胃散燥湿健脾、行气和胃的功效,复制相应的病理模型,将方中药物炮制前后分别组成平胃散进行药效学比较研究,探讨方中药物炮制入药的合理性。方法:将70只小鼠随机等分为正常组、模型组、阳性药物组、生品组、麸炒苍术组、炙甘草组、炮制品组,除正常组外,其余各组小鼠采用饮食不节、外湿过盛、情志不遂的综合方法复制湿困脾胃证病理模型,给药量约为0.01 m L·g^(-1);以小肠推进率、胃残留率及力竭游泳时间等为平胃散干预治疗的评价指标。结果:与正常组相比,模型组胃排空、小肠推进及抗疲劳能力极显著下降,说明造模成功。与模型组相比,各给药组均有明显的改善作用,其中阳性组与炮制品平胃散组的改善作用最显著。结论:平胃散在改善湿困脾胃证时,苍术与甘草以炮制品入药的药效更佳。Objective： Based on copy corresponding pathologic model, to discuss rationality of processing by comparing pharmacodynamics of Pingwei San. Method： Rats were divided into seven groups randomly,such as the normal group,the model group,the positive group,Pingwei San group,Pingwei San with processed Glycyrrhizae Radix et Rhizoma group, Pingweisan with processed Atractylodis Rhizoma group and Pingwei San with processed products group. In addition to the normal group,models caused by improper dieting,excessive external dampness and emotional discomfort with the spleen and stomach being stranded by dampness.Propulsive rate of the small intestine,gastric residual rate and swimming exhaustion time were taken as evaluation indexes for treatment of Pingwei San. Result： Compared with the normal group,gastric residual rate,propulsive rate of the small intestine and anti-fatigue capability of the model group decreased significantly,which manifested the model was successful. Compared with the model group,each treatment group had a significant improvement effect,while the positive group and Pingwei San with processed products group had the greatest effect.Conclusion： After Glycyrrhizae Radix et Rhizoma and Atractylodis Rhizoma in Pingwei San being processed,this prescription is preferable for improving dampness obstructing spleen-stomach syndrome.

关 键 词：平胃散 湿困脾胃证 药效学 苍术 小肠推进率 胃残留率 

分 类 号：R283.1[医药卫生—中药学] R285.5[医药卫生—中医学]