从药物代谢动力学角度探讨中药复方有效性的思路与方法  

Thinking and Methods for Demonstrating the Effectiveness of Chinese Herbal Compounds from the Perspective of Pharmacokinetics

作　　者：苏如玉[1] 张磊[1] 张玉[1] 闫蓉[1] 侯雪芹[1] 屈赵 杨从[1] 陈云波[1] 王奇[1] 

机构地区：[1]广州中医药大学临床药理研究所,广州510405

出　　处：《中国中西医结合杂志》2016年第1期111-115,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(No.81273817;No.81473740)

摘　　要：药物产生药理作用(治疗作用或毒副作用)的前提是达到一定的血药浓度。中药复方可以通过其多种成分间的相互作用,调节某种活性成分的血药浓度,从而使其发挥更好的治疗作用,或者降低其毒副作用。药物代谢动力学可以用来探讨中药复方是如何通过改变药物体内代谢过程以达到更好的疗效。To exert pharmacological effects,no matter therapeutic effect or toxic/side effect,it′s necessary to achieve enough plasma concentration.Chinese medical compounds,which contain various ingredients,influence the metabolism of some active ingredients through the interaction of ingredients to improve curative effects or reduce toxic/side effects.Pharmacokinetics can be used to explore how Chinese medical compounds influence the in vivo metabolism of some active ingredients to achieve better curative effects.

关 键 词：中药复方 有效性 药物代谢动力学 生物利用度 血药浓度 

分 类 号：R285.5[医药卫生—中药学]