系统评价盐酸氨溴索注射液静脉滴注联合雾化吸入治疗新生儿肺炎的疗效和安全性  

Systematic Review of Efficacy and Safety of Ambroxol Hydrochloride Injection by Intravenous Drip Combined with Aerosol Inhalation in the Treatment of Neonatal Pneumonia

作　　者：池卫明 廖华[2] 

机构地区：[1]湖北省中山医院药学部,武汉430033 [2]黄石市中心医院,湖北黄石435000

出　　处：《中国药房》2016年第3期341-344,共4页China Pharmacy

基　　金：黄石市医药卫生立项科研项目(No.20100115)

摘　　要：目的:系统评价盐酸氨溴索注射液静脉滴注联合雾化吸入治疗新生儿肺炎的疗效和安全性,以为临床提供循证参考。方法:计算机检索Pub Med、Medline、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库和万方数据库,收集盐酸氨溴索注射液静脉滴注联合雾化吸入(试验组)对比单用盐酸氨溴索注射液静脉滴注(对照组)治疗新生儿肺炎的随机对照试验(RCT),对符合纳入标准的临床研究进行资料提取,并采用Cochrane系统评价员手册5.1.0进行质量评价,采用Rev Man 5.2统计软件进行Meta分析。结果:共纳入14项RCT,合计1 407例患儿。Meta分析结果显示,试验组患儿的临床总有效率[RR=1.19,95%CI(1.13,1.24),P<0.001]显著高于对照组,咳嗽消失时间[MD=-1.75,95%CI(-1.91,-1.58),P<0.001]、气喘消失时间[MD=-1.38,95%CI(-1.67,-1.08),P<0.001]、肺部啰音消失时间[MD=-1.44,95%CI(-1.77,-1.11),P<0.001]和住院天数[MD=-2.04,95%CI(-2.25,-1.82),P<0.001]均显著短于对照组,差异均有统计学意义;两组患儿不良反应发生率比较差异无统计学意义[RR=1.00,95%CI(0.49,2.05),P=1.00]。结论:盐酸氨溴索注射液静脉滴注联合雾化吸入治疗新生儿肺炎的疗效和安全性均较好。OBJECTIVE： To systemically review the efficacy and safety of Ambroxol hydrochloride injection by intravenous drip combined with aerosol inhalation in the treatment of neonatal pneumonia, and provide evidence-based reference for the clinical treatment. METHODS： Retrieved from PubMed, Medline, CBM, CJFD, VIP and Wanfang Database, randomized controlled trials （RCT） about Ambroxol hydrochloride injection by intravenous drip combined with aerosol inhalation （test group） versus Ambroxol hydrochloride injection alone （control group） in the treatment of neonatal pneumonia. Meta-analysis was performed by using Rev Man 5.2 software after data extracting and quality evaluating by Cochrane 5.1.0. RESULTS： Totally 14 RCTs were enrolled, involving 1 407 patients. Results of Meta-analysis showed the clinical efficacy[RR=1.19,95% CI（1.13, 1.24）, P〈0.001] in test group was significantly higher than control group, the time of cough disappearance[MD=- 1.75,95% CI（- 1.91,- 1.58）, P〈0.001], asthma disappearance[MD=- 1.38,95%CI（ - 1.67, - 1.08） ,P〈0.001] and pulmonary rales disappearance [MD= - 1.44,95%CI （ - 1.77, - 1.11）, P〈0.001] and hospitalization days[MD= - 2.04,95% CI （ - 2.25, - 1.82）, P〈0.001] were significantly shorter than control group, the differences were statistically significant; and there was no significant difference in the incidence of adverse reactions between 2 groups[RR= 1.00,95 % CI （0.49,2.05）, P = 1.00]. CONCLUSIONS： Both the efficacy and safety of Ambroxol hydrochloride injection by intravenous drip combined with aerosol inhalation are good in the treatment of neonatal pneumonia.

关 键 词：氨溴索 雾化吸入 新生儿 肺炎 Meta分析 疗效 安全性 

分 类 号：R725.6[医药卫生—儿科]