聚乳酸-羟基乙酸载药微球制备工艺研究进展  

Preparation technique of drug-loaded microsphere by using poly lactic-co-glycolic acid

作　　者：韩斐[1,2] 胡懿郃[1] 汪龙[1] 

机构地区：[1]中南大学湘雅医院骨科,湖南长沙410078 [2]新疆医科大学,新疆乌鲁木齐830000

出　　处：《中国医学物理学杂志》2016年第1期92-97,共6页Chinese Journal of Medical Physics

基　　金：湖南省自然科学基金重点项目(12JJ2055);湖南省卫生计生委科研基金(132015-005)

摘　　要：聚乳酸-羟基乙酸(PLGA)作为一种具有良好生物相容性的可降解功能高分子化合物,在生物医学领域中展现了其重要作用。以PLGA为材料制备载药微球的方法有乳化溶剂挥发法、相分离法、盐析法、喷雾干燥法、膜乳化法、纳米沉淀法、超临界流体技术等。通过查阅国内外文献,总结PLGA载药微球各种制备技术的原理及优缺点,以及各方法近年来的研究进展。As a well biocompatible and biodegradable polymer, poly lactic-co-glycolic acid （PLGA） is very important in the biomedical field. The measures for preparing microsphere by using PLGA includes emulsion-solvent evaporation, phase separation, salting-out method, spray drying method, membrane emulsification, nanoprecipitation, supercritical fluid technology and so on. The principle, advantage and disadvantage, and research progress of mentioned techniques were summarized by analyzing domestic and foreign literatures.

关 键 词：聚乳酸-羟基乙酸 载药微球 制备 综述 

分 类 号：R94[医药卫生—药剂学]