复方吡拉西坦与吡拉西坦治疗中老年良性记忆减退疗效比较  

Piracetam and piracetam compound in treating benign hypomnesis of middle-sentle patients

作　　者：李淑兰[1] 杜尊铭 徐嗣荪 

机构地区：[1]杭州铁路中心医院,杭州310009 [2]浙江省精神卫生研究所

出　　处：《中国临床药理学与治疗学杂志》1997年第2期109-110,共2页

摘　　要：目的 比较复方吡拉西坦与吡拉西坦治疗中老年良性记忆减退的疗效。方法 选择５０周岁以上中老年良性记忆减退患者 ６０例，随机双盲均分为 ２组。治疗组用复方吡拉西坦胶囊（吡拉西坦和胆碱）２粒，ｐｏ，ｔｉｄ；对照组用吡拉西坦胶囊 ２粒，ｐｏ，ｔｉｄ，一个疗程 ６０ｄ。结果 治疗组记忆商（ＭＱ）和简易精神状态量表（ＭＭＳＥ）评分分别增加２４．３±１０．９和２．１±１．７；对照组分别增加1１．９± ６．３和 １．５ ±１．０，两组的 ＭＱ和 ＭＭＳＥ治疗前后自身对比均有非常显著差异（Ｐ＜０．０１），但治疗组疗末ＭＱ值比对照组疗末ＭＱ值明显增高（Ｐ＜ ０．０１）。结论 复方吡拉西坦治疗中老年良性记忆减退较吡拉西坦疗效更显著。Aim: and Methods To study the clinical effect of piracetam compound(PC) and piracetam on benign hypomnesis in middle-senile patients, double-blind method was adopted to devide 60 patients(M42, F18, age 58.0 ± 7. 6a) into two equal groups. Patients in group A received PC 2 capsules, po, tid for 60 days, while the patients in group B received pirac-etam. Results The memory quotient(MQ) and MMSE were increased by24. 3 ± 10. 9 and 2.1±1.7 in group A and 11.9± 6.3 and 1,5± 1.0 in group B. The MQ ivas increased more significantly in group A than in group B(P< 0. 01) . Conclusion Piracetam compound has better effect than piracetam alone in treating middle-senile benign hypomnesis.

关 键 词：复方吡拉西坦 吡拉西坦 治疗 记忆减退 疗效比较 中老年人 

分 类 号：R971[医药卫生—药品]