芒硝与生大黄内服联合治疗重症急性胰腺炎腹胀  

Clinical effect of mirabilite combined with raw rhubarb by oral administration for treatment of abdominal distension in severe acute pancreatitis

作　　者：李应 陈虹余 曾华波 

机构地区：[1]南充市高坪区人民医院,四川637100

出　　处：《现代医药卫生》2016年第2期195-196,199,共3页Journal of Modern Medicine & Health

摘　　要：目的探讨芒硝与生大黄内服联合治疗重症急性胰腺炎(SAP)腹胀的临床疗效。方法选取该院2013年1月至2015年5月收治的SAP患者60例,按照随机数字表法分为对照组和联合组,各30例。对照组采用常规方法治疗,联合组在常规治疗的基础上内服芒硝和生大黄,观察比较两组的临床疗效。结果联合组患者临床症状改善时间(腹胀、腹痛症状缓解情况,进食时间,身体相关指标恢复时间,通气排便时间,胃肠减压时间,住院时间等)明显短于对照组,治疗后并发症发生率、死亡率低于对照组,差异均有统计学意义(P<0.05);同时,两组患者治疗后C反应蛋白、肿瘤坏死因子-α水平均较治疗前降低,且联合组较对照组降低更明显,差异均有统计学意义(P<0.05)。联合组患者愈合情况明显优于对照组,差异有统计学意义(P<0.05)。结论芒硝与生大黄内服联合治疗SAP腹胀的临床疗效显著,值得在临床推广应用。Objective To explore the clinical effect of combined oral administration of mirabilite and raw rhubarb for treating abdominal distention in severe acute pancreatitis （SAP）. Methods 60 cases of SAP in our hospital from January 2013 to May 2015 were selected and divided into the control group and the combined group according to the random number table method,30 cases in each group. The control group was treated with the conventional therapy,while on this basis the combined group was given the oral administration of mirabilite and raw rhubarb. The clinical efficacies were observed and compared be- tween the two groups. Results The improvement time of clinical symptoms （alleviated situation of abdominal distension and ab- dominal pain, eating time, recovery time of related indicators, exhausted time and defecating time, gastrointestinal decompression time and hospitalization time, etc. ） in the combined group was significantly shorter than that of the control group, the occurrence rate and death rate after treatment in the combined group were lower than those in the control group, the differences were statistically significant （P〈0.05） ;at the same time, the levels of serum C-reactive protein （CRP） and tumor necrosis factor α （TNF-α） after treatment in the two groups were decreased compared with before treatment, moreover the decrease in the combined group was more obvious than that in the control group, the difference was statistically significant （P〈0.05）. The cure situation in the combined group was significantly superior to the control group with statistical difference（P〈0.05）. Conclusion The oral administration of mirabilite and raw rhubarb for treating abdominal distention in SAP has significant clinical effect and is worth being widely popu- larized and applied in clinic.

关 键 词：芒硝/治疗应用 大黄属 危重病 胰腺炎 急性病 

分 类 号：R657.51[医药卫生—外科学]