血浆PAI-1、胱抑素C与2型糖尿病合并颈动脉粥样硬化的相关性  

The correlation between the levels of serum PAI-1, Cystatin C and carotid atherosclerosis in type 2 diabetic mellitus patients

作　　者：刘英晓 董春玉 

机构地区：[1]威海市中心医院内分泌科,264400

出　　处：《国际医药卫生导报》2016年第1期54-56,共3页International Medicine and Health Guidance News

摘　　要：目的探讨血浆PAI—1、CysC与2型糖尿病合并颈动脉粥样硬化的关系。方法用放射免疫法及生物化学法检测133例患者血浆PAI—1、胱抑素C水平。结果（1）2型糖尿病合并颈动脉粥样硬化组血浆PAI-1、胱抑素C水平与正常对照组、单纯2型糖尿病组比较差异有统计学意义俨〈0．05）。（2）回归分析显示：PAI-1、CysC与2型糖尿病合并颈动脉粥样硬化独立相关（OR=1．133、1．012E7，P〈0．01）。结论PAI-1、CysC与2型糖尿病合并颈动脉粥样硬化相关，可能成为2型糖尿病合并颈动脉粥样硬化患者的预测指标。Objective To investigate the correlation between the levels of serum PAI-1, Cystatin C and carotid atherosclerosis in type 2 diabetic mellitus （T2DM） patients. Method Detected the levels of serum PAI-1 and Cystatin C with RIA and physiological chemistry in 133 T2DM patients. Results （1） The levels of serum PAI-1 and Cystatin C in patients with carotid atherosclerosis were significantly higher than those in patients without carotid atherosclerosis and control group （P〈0.05）. （2） Logistic analysis showed that the levels of serum PAI-1 and Cystatin C were independently related to carotid atherosclerosis in type 2 diabetic mellitus patients （OR= 1.133, 1.012E7; P〈0.01）. Conclusions PAI-1 and Cystatin C play the important role in carotid atherosclerosis in T2DM patients, which may be the forecast indexes of carotid atherosclerosis in T2DM patients.

关 键 词：PAI-1 胱抑素C 2型糖尿病 颈动脉粥样硬化 

分 类 号：R543.4[医药卫生—心血管疾病]