石杉碱甲片对良性衰老性遗忘症记忆和认识的疗效(英文)  

Efficacy of tablet huperzine － A on memory and cognition in patients with benign senescent forgetfulness

作　　者：徐嗣荪[1] 谢海宝[2] 杜尊铭 童振华[1] 石其昌 吕克明 李淑兰[3] 林兵 

机构地区：[1]浙江省药物监用监测站,浙江医科大学杭州310006 [2]浙江江医院 [3]杭州铁路中心医院

出　　处：《中国临床药理学与治疗学杂志》1997年第1期1-4,共4页

摘　　要：目的 评估石杉碱甲片治疗良性衰老性遗忘症的疗效及其安全性。方法 采用多中心，前瞻性，双盲，空白对照和随机方法，各给５０例良性衰老性遗忘症以石杉碱甲片３片（每片含５０微克）或安慰剂片，一日两次口服共四周，所有病人都用韦氏记忆量表，简明精神状态量表，副反应量表和其他实验室检查。结果 发现７４％（３７／５０）的石杉碱甲片服用者改善了记忆和认知能力，而安慰剂组仅为４０％（２０／５０），两组疗效有非常显著差（Ｘ２＝１１．７９，Ｐ＜０．０１），而两组均无严重不良反应发生。结论 石杉碱甲片是治疗良性衰老性遗忘症的理想药物。Aim To evaluate the efficacy and safety of tablet huperzine - A(Hup) in patients with benign senescent forgetfulness. Methods Using multicenter, prospective, double - blind, parallel, placebo controlled and randomized method, 50 patients were administrated orally 0.15mg (3 tablets ) Hup and 50 patients were given po 3 tablets of placebo bid for 4 wk. All patients were evaluated with Wechsler memory scale, mini - mental state examination scale, treatment emergency symptom scale, and measured BP, HR, ECG, EEG, ALT, AKP, BUN, Cr, Hb, WBC, and urine routine. Results Seventy four percent of patients treated with Hup (37/50) showed improvements in their memory (P<0.01 ) and cognitive functions(P<0.01). The efficacy of Hup was better than placebo(40%, 20/50) (P< 0. 05). No severe cholinergic side effect was found. Conclusion Hup is an ideal drug for symp- tomatic treatment of patients with benign senescent forgetfulness.

关 键 词：石杉碱甲片 良性衰老性遗忘症 记忆 认识 疗效 

分 类 号：R971[医药卫生—药品] R749.16[医药卫生—药学]