中国6省复治肺结核患者耐药情况调查  

Drug resistance among retreatment tuberculosis patients in six provinces of China

作　　者：徐彩红[1] 富韵婷[1] 阮云洲[1] 李仁忠[1] 陈明亭[1] 

机构地区：[1]中国疾病预防控制中心结核病预防控制中心,北京102206

出　　处：《中国公共卫生》2016年第1期59-61,共3页Chinese Journal of Public Health

基　　金：中国全球抗击艾滋病;结核病和疟疾基金项目(CHN-S10-G14-T)

摘　　要：目的了解广东、湖北、河南、山东、内蒙、浙江6个省复治肺结核患者的耐药情况,为制定耐药结核病相关策略提供科学依据。方法收集2008年1月—2010年12月广东、湖北、河南、山东、内蒙、浙江6个省筛查的7 338例复治肺结核患者的基本情况、涂片、培养、药物敏感试验、菌种鉴定等信息,应用SPSS 12.0统计软件分析不同登记分类复治肺结核患者的耐药情况。结果 6个省筛查的7 338例复治肺结核患者中,有7 290例开展了痰培养检验,培养结果阳性5 403例,并对培养阳性的患者全部开展药敏试验;药敏试验结果显示,复治肺结核患者任一耐药异烟肼耐药率为48.3%,利福平耐药率为45.8%,氧氟沙星耐药率为20.2%,卡那霉素耐药率为6.3%;复治肺结核患者耐多药率和广泛耐药率分别为36.6%和1.1%,其中复治失败患者耐多药率(56.3%)和广泛耐药率(3.0%)最高。结论复治肺结核患者任一耐药率和耐多药率均处于较高水平,其中复治失败患者耐药率最高。Objective To analyze the prevalence of drug resistance among retreatment pulmonary tuberculosis （TB） patients in 6 provinces of China and to provide evidences for making strategies on the control of drug-resistant TB. Methods Information on demographics,results of sputum smear,bacteria isolation and identification and drug sensi- tivity test（DST） for 7 338 retreatment TB patients were collected from Guangdong, Hubei, Henan, Shandong, and Zhe- jiang province and Inner Mongolia Autonomous Region from January 2008 through December 2010. SPSS 12.0 was used to analyze differences in drug resistance among the patients. Results For all the retreatment TB patients ,7 290 had spu- tum culture for Mycobacterium tuberculosis detection, of which 5 403 had positive results and DST was conducted for all positive specimens. For all the strains isolated,48.3% were resistant to isoniazid,45.8% to rifampin,20. 2% to ofloxa- cin, and 6. 3 % to kanamycin and the ratio of multidrug resistant （MDR） and extensively drug resistant （XDR） were 36. 6% and 1.1% ,respectively. Among all the patients, those with ineffective medication had the highest prevalence of MDR（56. 3% ） and XDR（3. 1% ）. Conclusion The prevalence of MDR and XDR are at a high level among retreat- ment TB patients and the prevalence is the highest among the retreatment patients with ineffective medication.

关 键 词：肺结核 耐药 复治 

分 类 号：R521[医药卫生—内科学]