氯乙酸异丙酯的合成研究  

Research on Synthesis of Isopropyl Chloroacetate

作　　者：王杰[1] 李敢[1,2] 

机构地区：[1]徐州工业职业技术学院化学工程技术学院,江苏徐州221140 [2]江苏省化工新材料工程技术研究开发中心,江苏徐州221140

出　　处：《广州化工》2016年第2期19-20,共2页GuangZhou Chemical Industry

摘　　要：氯乙酸异丙酯是医药工业不可或缺的一种有机合成的中间体,被广泛用于合成非甾体类消炎解热镇痛药物萘普生和布洛芬的原料,需求量较大。因此对于氯乙酸异丙酯的研究越来越多,高效催化剂的选择不容小觑。参考近几年有关氯乙酸异丙酯合成的文献,发现无机盐、固体超强酸、功能化离子液体等催化剂在使用中的优缺点。Isopropyl chloroacetate is indispensable as a kind of organic synthesis intermediates in the pharmaceutical industry, and is widely used in the synthesis of non steroid body anti-inflammatory antipyretie analgesic drug naproxen and ibuprofen raw materials, demand is great. So bescuse more and more peoples are researching on isopropyl chloroacetate, the choice of high efficiency catalyst should not be underestimated. The literatures about synthesizing isopropyl chloroacetate in recent years were consulted, the advantages and disadvantages in the process of using inorganic salt, solid super acid and functionalized ionic liquid as catalysts were found.

关 键 词：氯乙酸异丙酯 催化剂 酯化 

分 类 号：O643.36[理学—物理化学] TQ225.24[理学—化学]