原发性高血压患者心率变异性与肱踝脉搏波传导速度的相关性研究  

Correlation between the heart rate variability and brachial-ankel pulse wave velocity in patients with essential hypertension

作　　者：黎月琴 张源明[1] 杨黎[1] 贺思利 

机构地区：[1]新疆医科大学第一附属医院高血压科,乌鲁木齐830054

出　　处：《疑难病杂志》2016年第1期1-4,13,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金资助项目(H0214-81160039)

摘　　要：目的探讨原发性高血压患者心率变异性（HRV）与肱踝脉搏波传导速度（baPWV）的关系。方法选取2013年2月—2015年2月就诊于新疆医科大学第一附属医院高血压科的原发性高血压患者435例,根据彩色多普勒超声诊断,将baPWV〈1 400 cm/s患者123例作为正常组,baPWV≥1 400 cm/s患者312例作为升高组,检测患者各生化指标、体质量指数（BMI）,并记录24 h平均收缩压、24 h平均舒张压、白天平均收缩压、白天平均舒张压、夜间平均收缩压、夜间平均舒张压及心率变异性指标。对baPWV相关危险因素进行单因素分析和多因素Logistic回归分析。结果正常组与升高组比较,SDNN、SDANN、PNNS0等差异均有统计学意义（t=5.183、8.202、2.047,P〈0.05）,而RMSSD差异无统计学意义（t=1.797,P〉0.05）。汉族与维吾尔族心率变异性比较中,SDNN、SDANN差异有统计学意义（t=3.091、2.968,P〈0.05）。单因素分析中,baPWV与年龄、高血压病程、24 h平均收缩压、白天平均收缩压、夜间平均收缩压、夜间平均舒张压呈正相关（r=0.456、0.355、0.321、0.399、0.342、0.303,P均〈0.05）,与SDNN、SDANN、PNNS0呈负相关（r=-0.432、-0.502、-0.489,P均〈0.01）。经多因素Logistic回归分析显示,年龄、SDANN是影响baPWV的独立危险因素[OR（95%CI）=1.073（1.042~1.104）、0.978（0.966~0.990）,P〈0.05]。结论原发性高血压患者肱踝脉搏波传导速度与心率变异性,尤其是SDANN独立相关。Objective To investigate the relationship between heart rate variability（HRV） and brachial-ankel pulse wave velocity（baPWV） in patients with essential hypertension.Methods From February 2013 to February 2015,435 cases of primary hypertension patients who were treated in Department of hypertension,the First Affiliated Hospital of Xinjiang Medical University were enrolled,according to the color Doppler ultrasound,123 cases of baPWV 1 400 cm/s were selected as normal group,312 cases of patients with baPWV ≥1 400 cm/s were selected as elevated group,biochemical index,body mass index（BMI） and 24-hour mean systolic blood pressure record,24-hour mean diastolic blood pressure,daytime average systolic blood pressure,daytime average diastolic blood pressure,and night average systolic blood pressure,night mean diastolic blood pressure and heart rate variability（HRV） were detected.Univariate analysis and multivariate Logistic regression analysis of baPWV related risk factors were performed.Results The normal group and elevated group＇s SDNN,SDANN,pNN50＇s differences were statistically significant（t = 5.183 、8.202、2.047,P〈0.05）,and RMSSD＇s difference showed no statistical significance（t =1.797,P〉0.05）.Han and Uygur in the comparison of heart rate variability,the SDNN,SDANN＇s difference had statistical significance（t =3.091,t =2.968,P〈0.05）.From univariate analysis,baPWV and age,duration of hypertension,24 h mean systolic pressure,mean systolic pressure during daytime,nighttime average systolic blood pressure,nighttime mean diastolic blood pressure were positively correlated（r =0.456,r =0.355,r =0.321,r =0.399,r =0.342,r =0.103,all P〈0.05）,SDNN,SDANN,pNN50 were negative correlated（r =-0.432,r =-0.502,r =-0.489,all P〈0.01）.Multivariate Logistic regression analysis showed that,age,SDANN were the independent risk factors for PWV[OR（95%CI） =1.073（1.042-1.104）,OR（95%CI） =0.978（0.966-0.990）,P〈0.05].Conclusion Patients with essential hypertension＇s pulse w

关 键 词：肱踝脉搏波传导速度 心率变异性 高血压 原发性 

分 类 号：R544.11[医药卫生—心血管疾病]