卵泡抑素样蛋白-1在川崎病诊断及冠状动脉损害中的作用  

Role of follistatin-like protein-1 in Kawasaki disease diagnosis and its coronary arterial injury

作　　者：陈艳玲[1] 李小琳[1] 张莉[1] 彭建明[2] 官燕飞[2] 袁斌[2] 黄绍芬 

机构地区：[1]南方医科大学附属中山市博爱医院儿科,广东中山528403 [2]南方医科大学附属中山市博爱医院检验科,广东中山528403

出　　处：《检验医学与临床》2016年第2期179-180,183,共3页Laboratory Medicine and Clinic

基　　金：广东省中山市科技计划项目(2014A1FC011)

摘　　要：目的探讨卵泡抑素样蛋白-1(FSTL-1)水平与川崎病及冠状动脉损害的关联。方法选择48例川崎病患者为川崎病组,根据有无并发冠状动脉损害,分为川崎病并发冠状动脉损害组(4例)和无并发冠状动脉损害组(44例)。选择同期20例健康儿童作为健康对照组,采用酶联免疫吸附试验检测各组血清中的FSTL-1水平。结果与健康对照组相比,川崎病患者血清FSTL-1水平明显升高,差异有统计学意义(P<0.05);并发冠状动脉损伤的患者其FSTL-1水平明显高于无冠状动脉损害的患者,差异有统计学意义(P<0.05)。结论 FSTL-1水平与川崎病存在一定的相关性,有用于川崎病相关冠状动脉损害诊断的可能。Objective To investigate the correlation between serum levels of follistatin-like protein-1（FSTL-1）with Kawasaki disease（KD）and its coronary arterial injury.Methods 48 patients with KD were selected as the KD group and divided into the KD disease complicating coronary arterial injury group（4cases）and the KD disease without complicating coronary arterial injury group（44cases）.Contemporaneous 20 healthy children were selected as the control group.Serum FSTL-1 levels were measured by ELISA in each group.Results Serum FSTL-1 level in the KD patients was elevated as compared with the control group,the difference was statistically significant（P〈0.05）.Serum FSTL-1 level in the KD patients complicating coronary arterial injury was significantly higher than that in the KD patients without complicating coronary arterial injury,the difference was statistically significant（P〈0.05）.Conclusion There is certain correlation between serum FSTL-1 level with KD,which has possibility for the application in diagnosing KD related coronary arterial injury.

关 键 词：川崎病 卵泡抑素样蛋白-1 冠状动脉损害 

分 类 号：R725.97[医药卫生—儿科]