基于混料均匀设计的肺纤维化的中药复方优化  

Optimizing a Formula for Pulmonary Fibrosis Treatment by Mixture Uniform Experiment Design

作　　者：倪博文[1] 吴谦[2] 王淑艳[2] 范盎然[2] 葛东宇[2] 耿青霞[2] 陈萌[2] 李丽娜[2] 

机构地区：[1]威海市立医院中医科,山东威海264200 [2]北京中医药大学基础医学院,北京100029

出　　处：《中华中医药学刊》2016年第1期76-78,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81173192)

摘　　要：目的:以临床常用治疗肺纤维化的中药为基础,优化治疗肺纤维化的中药复方。方法:参考临床治疗肺纤维化中药复方用药规律的数据挖掘结果,选取12味临床常用的治疗肺纤维化的药物,利用混料均匀设计方法获得11个药味相同而组成比例不同的复方,在小鼠IPF模型中以小鼠死亡率为优化指标优化复方并加以验证。结果:得到一个优化复方,其对小鼠死亡率的影响与原方5无差异,而拮抗纤维化的作用优于原方5。优化所得复方与设计方案中的两个最佳复方的主要组成药物均属于益气、活血、滋阴、宣肺四类,而3个复方中含量最小的药物均为燥湿化痰药半夏。结论:益气活血滋阴宣肺有利于肺纤维化模型小鼠的生存,燥湿化痰类药物可能不利于肺纤维化模型小鼠的生存。Objective： To optimize a formula for pulmonary fibrosis treatment,which was commonly used in clinic.Methods： Referring the data mining results on the formula building- up,we chose 12 kinds of herbs which were frequently used in clinic for treating lung fibrosis. A test was designed by mixture uniform experiment design and 11 formulae were got（ the original formulae）,which had the same herbs but different composition ratios. All the formulae were used in mice IPF model and the mortality rates were observed and used as optimization target. Results： A new formula was got. It had the same effect with the 5th original formula and had better effect on anti- fibrosis. Both the 2ndand the 5thoriginal formulae and the new formula had the similar composition： they all had 4 kinds of herbs： invigorating Qi,invigorating blood circulation,nourishing Yin and freeing lung. And the minimal content in the tree formulae were Pinellia ternata,which belonged to damp- drying and phlegm- resolving herbs. Conclusion： The herbs which had the effect on invigorating Qi,invigorating blood circulation,nourishing Yin and freeing lung could be propitious to the survival of IPF model mice. And the damp- drying and phlegm- resolving herbs made against IPF mice survival.

关 键 词：混料均匀设计 肺纤维化 复方优化 益气活血 滋阴宣肺 

分 类 号：R-332[医药卫生]