运脾消食颗粒对厌食症大鼠模型胃窦部胃泌素和血清八肽胆囊收缩素调节作用的研究  

Study on Yunpi Xiaoshi Particles Regulating Gastrin of Gastric Antrum and Serum CCK-8 of Model of Anorexia Rats

作　　者：杜晨光[1] 徐丁洁[1] 丁培杰[1] 曹颖[1] 郑彩慧[1] 白素芬[1] 柳月娟[1] 董玉山[1] 

机构地区：[1]河北联合大学中医学院

出　　处：《中华中医药学刊》2016年第1期160-162,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省中医药管理局指令项目(2014054);唐山市科技局指导项目(13130216b)

摘　　要：目的:探讨运脾消食颗粒对厌食症大鼠模型胃泌素(gastrin)、八肽胆囊收缩素(CCK-8)含量的影响。方法:采用病因模拟法建立小儿厌食症动物模型,分别对模型大鼠摄食量、体质量以及gastrin、CCK-8含量进行检测。结果:运脾消食颗粒可以明显增强厌食症大鼠的食欲,增加体质量,提高胃窦部gastrin含量,降低血清CCK-8含量,与模型对照组比较,差异均有统计学意义(P<0.05或P<0.01)。结论:运脾消食颗粒对厌食症模型具有明显治疗作用。其发挥临床疗效的作用机制可能是通过调节gastrin、CCK-8含量实现的。Objective： To study the influence of Yunpi Xiaoshi Particles on gastrin and CCK- 8 levels of rats model of anorexia. Methods： The etiology simulation method was adopted to establish the animal model of infantile anorexia. The food intake,weight of model rats and gastrin and CCK- 8 contents were tested. Results： Yunpi Xiaoshi Particles can significantly enhance the appetite of anorexia rats and weight gain and increase the gastrin of gastric antrum and reduce the serum CCK- 8 levels. Compared with the model control group,the difference had statistical significance（ P 〈0. 05 or P〈0. 01）. Conclusion： Yunpi Xiaoshi Particles has obvious therapeutic effect on anorexia model. The mechanism may be through regulating gastrin and CCK- 8 content in the implementation.

关 键 词：运脾消食颗粒 厌食症模型 胃泌素 八肽胆囊收缩素 

分 类 号：R285.5[医药卫生—中药学]