慢性头痛患儿血清弓形虫循环抗原、抗体检测及临床分析  

Children with chronic headache toxoplasma circulating antigen,serum antibody detection andclinical analysis

作　　者：原慧芳[1] 阮秀花[1] 张效本[1] 毋晶晶[1] 

机构地区：[1]开封市医学科学研究所,河南开封475000

出　　处：《河南预防医学杂志》2016年第3期174-176,共3页Henan Journal of Preventive Medicine

摘　　要：目的检测慢性头痛患儿血清中弓形虫循环抗原、抗体的感染分布情况,以了解小儿慢性头痛与弓形虫感染的相关性。方法选择152例慢性头痛患儿作为病例组,45例健康体检者作为对照组,分别对其血清弓形虫循环抗原(Cag)、抗体(IgM、IgG)进行检测。结果慢性头痛患儿血清中弓形虫循环抗原抗体检测阳性率为67.10%,高于健康体检组(11.11%),2组阳性率差异有有统计学意义(P<0.01)。慢性头痛组以抗体IgG比例最高,为67.65%(69/102),其中单一IgG为36.27%(37/102),与其他抗原抗体比较,差异具有统计学意义(P<0.05);其次为IgM单独或与IgG、Cag共同存在占55.88%(57/102)。结论本研究提示进行弓形虫抗原抗体检测,对不明原因头痛尤其有宠物接触史的患儿明确病因,指导临床治疗,有一定的应用价值。Objective To detect the serum Toxoplasma gondii chronic headache in children with insect circulating antigen, antibody of infection distribution, in order to understand the relationship between chronic headache in children infected with Toxoplasma gondii. Methods 152 cases of chronic headache patients as case group, 45 healthy volunteers as control group, the serum Toxoplasma circulating antigen （Cag）, antibody （IgM, IgG） were detected. Results the detection of circulating antigens of Toxoplasma antibody positive rate of serum in patients with chronic headache was 67.10 %, higher than the healthy group （11.11% ）, there are significant differences between the two group the positive rate, there was statistically significant （P〈0.01）. The chronic headache group with the highest proportion of antibody IgG 67.65 % （69/102）, in which a single IgG was 36.27 % （37/102）, compared with other antigen antibody, the difference was significant （P〈0.05） ： followed by IgM alone or co existed with IgG, Cag accounted for 55.88 % （57/102）. Conclusion this study indicated that the detection of Toxoplasma gondii antigen antibody, especially PET contact history with definite causes of unexplained headache, clinical treatment, have certain application value.

关 键 词：慢性头痛 弓形虫 循环抗原 抗体 

分 类 号：R531.8[医药卫生—内科学]