血清γ谷氨酰转移酶:急性心力衰竭患者死亡的风险因素  

Serum gamma-glutamyl transferase:a risk factor of mortality in patients with acute heart failure

作　　者：葛金莲[1] 姜艳[1] 顾挺[1] 张明琛[1] 热依哈尼.阿比迪西赫提 

机构地区：[1]新疆医科大学第一附属医院医学检验中心,乌鲁木齐830011

出　　处：《岭南心血管病杂志》2016年第1期62-65,共4页South China Journal of Cardiovascular Diseases

基　　金：新疆维吾尔自治区科学自然基金(项目编号:2012211A067)

摘　　要：目的探讨血清γ谷氨酰转移酶(gamma-glutamyl transferase,γ-GGT)对急性心力衰竭(acute heart failure,AHF)患者病死率的预测价值。方法将188例AHF患者分为死亡组和存活组,所有患者行生物化学以及血清γ-GGT浓度检测,分析两组患者的血清γ-GGT浓度及临床生化指标的差异。结果两组血清γ-GGT浓度、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、血尿素氮(blood urea nitrogen,BUN)、血肌酐(creatinine,Cr)、肌酸激酶(creatine kinase,CK)、肌酸激酶同工酶(creatine kinase isoenzyme MB,CK-MB)、总胆汁酸(total bile acid,TBA)、心房脑钠肽(brain natriuretic peptide,BNP)浓度,射血分数(ejection fraction,EF)及合并原发性高血压(高血压)、心房纤颤患者比例比较,差异具有统计学意义(P<0.05)。应用Logistic回归分析显示,血清γ-GGT浓度为AHF患者的危险因素(P<0.05)。血清γ-GGT浓度对于AHF病死率的诊断的敏感度78.9%,特异度66.7%,受试者工作曲线下面积为0.759。结论血清γ-GGT浓度可能可以作为预测AHF的病死率的血清指标,具有一定的临床应用价值。Objectives To explore the predictive value of serum gamma-glutamyl transferase （γ-GGT） on mortality in patients with acute heart failure （AHF）. Methods A total of 188 patients with AHF were divided into death group and survival group. Biochemical indexes and serum concentration of γ-GGT were tested in all the patients to analyze the differences between the two groups. Results There were significant differences in serum concentrations of γ-GGT, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, blood urea nitrogen （BUN）, creatinine （Cr）, creatine kinase isoenzyme MB （CK-MB）, total bile acid （TBA）, brain natriuretic peptide （BNP）, ejection fraction （EF） and percentages of patients with atrial titillation, hypertension between the two groups （P〈0.05）. Logistic regression analysis showed that serum concentration of γ-GGT was an independent risk factor in patients with AHF （P〈0.05）. The sensitivity and specificity were 78.9% and 66.4% with a cutoff value of 35.5 U/L. The area under the receiver operating characteristic curve was 0.759. Conclusions Serum concentration of γ-GGT may be a predictor of mortality in patients with AHF. It has clinical diagnostic value to a certain extent.

关 键 词：急性心力衰竭 Γ-谷氨酰转移酶 风险因素 

分 类 号：R541.6[医药卫生—心血管疾病]