壮骨肾宝对实验性小鼠高脂血症的影响  

Effects of Zhuanggushenbao on hyperlipoidemia in mice

作　　者：杨燕[1] 吴铁[1] 艾春媚[1] 何康[1] 崔燎[1] 

机构地区：[1]广东医学院药理教研室,湛江524023

出　　处：《中国临床药理学与治疗学杂志》1997年第4期273-275,共3页

摘　　要：目的观察由黄芪、白术、淫羊藿组成的复方制剂(壮骨肾宝)对实验性小鼠高脂血症的影响。方法用蛋黄乳液快速致小鼠单纯性高胆固醇血症和喂养高脂饲料致高脂血症模型 ,观察预防性给予不同剂量的壮骨肾宝后对血清总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL -ch)的影响。结果壮骨肾宝中、高剂量能使血清TC降低(P<0.05),HDL -ch升高(P<0.01) ,但对TG的影响不大。结论壮骨肾宝有一定降血脂作用 。Aim The action of lowing serum lipid of Zhuanggushenbao, which was prepared from Epimedium, Astragalus L and Atractylodes, was observed. Methods Mouse hypercholesterolemia model by injecting yolk and mouse hyperlipoidemia model by fedding high lipid foods were set up. The effects of Zhuanggushenbao in its low , medium and high dose on serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein-chlesterol (HDL-ch) were studied. Results Medium and high dose Zhuanggushenbao could reduce serum TC (P<0.05), and increase HDL-ch obviously (P<0.01). But it could not affect serum TG nearly. Conclusion Zhuanggushenbao has a dose-effect relationship on lowing blood lipid.

关 键 词：壮骨肾宝 小鼠 高脂血症 实验研究 

分 类 号：R285.5[医药卫生—中药学] R259.892[医药卫生—中医学]