3-甲基苯丙酮的合成方法研究  

Synthesis of 3-Methypropiophenone

作　　者：黄朋勉[1] 唐文娟[1] 吴莹[1] 黄子杰[1] 易霞[1] 周智慧[1] 

机构地区：[1]长沙理工大学化学与生物工程学院,湖南长沙410114

出　　处：《精细化工中间体》2015年第6期23-25,共3页Fine Chemical Intermediates

基　　金：湖南省教育厅项目资助(15C0022)

摘　　要：以溴乙烷和镁屑为原料,四氢呋喃为溶剂制备乙基溴化镁格氏试剂。格氏试剂和间甲基苯甲醛反应得到3′-甲基苯丙醇,随后采用氯铬酸吡啶鎓盐(Pcc)氧化得到产品3′-甲基苯丙酮。收率为72%,纯度为98%(HPLC)。优化反应条件为:n(溴乙烷)∶n(镁屑)∶n(间甲基苯甲醛)=1.2∶1.1∶1.0,氧化反应温度为40℃。Grignard reagent-ethyl magnesium bromide was prepared using bromoethane and magnesium in tetrahydrofuran. 1-（3-Methyl-phenyl）-propan-1-ol was obtained by the reaction of ethyl magnesium bromide with m-tolualdehyde. 3-Methylpropiophenone was obtained from the oxidation reaction of 1-（3-methyl-phenyl）-propan-1-ol using pyridinium chlorochromate（PCC） with a yield of 72% and purity of 98%（HPLC）. The optimal reaction conditions were as following： the molar ratio of bromoethane, magnesium and m-tolualdehyde was of 1.2：1.1：1.0, and the oxidation reaction temperature was of 40℃.

关 键 词：格氏试剂 间甲基苯甲醛 3′-甲基苯丙酮 PCC 

分 类 号：O625.42[理学—有机化学]